Neuromuscular Characteristics of Rocuronium in Diabetic Patients
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cukurova Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: In diabetic patients, there may be obsserved functional loss of motor nerve fibers and this fact may affect the management of anesthesia in many ways. In our study we aimed to research if there is any differences between nondiabetic patients and the patients who have type 2 diabetes on the side of nueromuscular blockade characteristics of rocuronium. Material and Methods: 18 diabetic and 21 non-diabetic patients included to study, each patient evaluated by the NMT device after administiration of 0,6 mg/kg rocuronium intravenously. The onset of action time, clinical acting time, recovery time, total rocuronium dosage for each patient, amplitude of supramaximal excitation and Goldberg score were compared in the two groups. Results: Time of action (118,33 +/- 41,61 sn. & 142,00 +/- 28,68 sn.) and recovery time (13,33 +/- 9,83 dak. & 22,38 +/- 11,64 dak.) were longer than in diabetic patients (p<0,05), time of action and amplitude of supramaximal excitation were similar in two groups (p>0,05). Conclusion: We consider that the prolongation of onset of action time and recovery time in diabetic patients, is a complicaiton of diabetic neuropathy and diabetes may effect the pharmacodynamics of rocuronium.
Açıklama
Anahtar Kelimeler
Nneuromuscular Block, Rocuronium, Diabetes, General Anesthesia
Kaynak
Cukurova Medical Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
39
Sayı
4
