Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorFerahkaya, Hursit
dc.contributor.authorKaragoez, Huelya
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorEnergin, Vesile Meltem
dc.date.accessioned2024-02-23T14:20:16Z
dc.date.available2024-02-23T14:20:16Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractAim Increased intestinal and blood-brain barriers (BBB) permeability has been suggested to have a role in autism spectrum disorder (ASD). Claudin-5, claudin-11, occludin, beta-catenin, vinculin, and paxillin are crucial components of these barriers. This study assessed concentrations of these molecules in preschool children with ASD.Methods A total of 80 children with ASD and 40 controls aged 18-60 months were enrolled in this study. Serum levels of biochemical variables were determined using commercial enzyme-linked immunosorbent assay kits.Results Serum claudin-11, occludin, and beta-catenin levels were significantly higher in the ASD group than in the control group. However, no significant difference for serum claudin-5, vinculin, and paxillin levels was detected between the groups.Conclusion These findings suggest that claudin-11, occludin, and beta-catenin may be involved in the pathogenesis of ASD. These proteins may affect the brain by causing dysregulation in intestinal or blood-brain barrier permeability or with other unknown mechanisms.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [201218015]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University [Project no: 201218015].en_US
dc.identifier.doi10.1080/08039488.2023.2168055
dc.identifier.endpage511en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue5en_US
dc.identifier.pmid36662163en_US
dc.identifier.scopus2-s2.0-85147031096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage506en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2023.2168055
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13092
dc.identifier.volume77en_US
dc.identifier.wosWOS:000918371700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism Spectrum Disorderen_US
dc.subjectClaudinen_US
dc.subjectOccludinen_US
dc.subjectBeta-Cateninen_US
dc.subjectVinculinen_US
dc.subjectPaxillinen_US
dc.titleSerum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorderen_US
dc.typeArticleen_US

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