Disposable electrochemical flow cell with paper-based electrode assemble

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dc.contributor.authorTorul, Hilal
dc.contributor.authorGumustas, Mehmet
dc.contributor.authorUrguplu, Berat
dc.contributor.authorUzunoglu, Aytekin
dc.contributor.authorBoyaci, Ismail Hakki
dc.contributor.authorCelikkan, Huseyin
dc.contributor.authorTamer, Ugur
dc.date.accessioned2024-02-23T14:12:47Z
dc.date.available2024-02-23T14:12:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractHigh performance liquid chromatography-electrochemical detector (HPLC-EC) is employed as a reliable device for the detection of catecholamines in blood or urine samples without any time-consuming extraction procedure. However, there is a need for the construction of cheap and easy-to-operate electrode assemble systems embedded in HPLC-EC. In this study, we present a disposable and low-cost paper-based electrode (PBE) assemble utilizing a nitrocellulose membrane, which serves support material in flow-cell device for HPLC-EC. A custom-built flow cell was inventively designed as specific to the prepared PBEs via stereolithography 3D printing. To gain the electrochemical signal enhancement, the working electrode was modified with gold nanoparticles and carboxylated-multi-walled carbon nanotubes (MWCNTs). Here, we focused on the construction of the paper-based electrode assemble and characterization of the flow cell device performance. To demonstrate the functionality of the flow cell device, we analyzed common catecholamines from spiked biological fluids using the optimized experimental parameters. Amperometric detection of the catecholamines was carried out at the potential of + 0.5 V and linear range was found to be 0.5-20.0 mu g/mL, with a limit of detection in the range of 4.0-15.0 ng/mL. The obtained results confirmed our disposable paper-based electrode assemble to be promising for the construction of an electrochemical platform for reliable and fast detection of electroactive species.en_US
dc.description.sponsorshipGazi University Scientific Research Department (Ankara, Turkey) [02/2019-16]en_US
dc.description.sponsorshipWe thank to Alparslan Kilic for providing technical support. This study was supported by Gazi University Scientific Research Department (Ankara, Turkey; Project No. 02/2019-16).en_US
dc.identifier.doi10.1016/j.jelechem.2021.115268
dc.identifier.issn1572-6657
dc.identifier.issn1873-2569
dc.identifier.scopus2-s2.0-85105696315en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jelechem.2021.115268
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12178
dc.identifier.volume891en_US
dc.identifier.wosWOS:000653066300002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Electroanalytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlow-Cellen_US
dc.subjectPaper-Based Electrodeen_US
dc.subjectHplc-Ecen_US
dc.subjectCatecholaminesen_US
dc.subjectBlooden_US
dc.subjectUrineen_US
dc.titleDisposable electrochemical flow cell with paper-based electrode assembleen_US
dc.typeArticleen_US

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