Paramagnetic characterization and dosimetric properties of Airfix drug and its ingredients (Montelukast sodium, Sorbitol): An EPR and DFT study

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dc.contributor.authorEce, Emel
dc.contributor.authorTasdemir, Halil Ugur
dc.contributor.authorBiyik, Recep
dc.contributor.authorOzmen, Ayhan
dc.contributor.authorSayin, Ulku
dc.date.accessioned2024-02-23T14:13:40Z
dc.date.available2024-02-23T14:13:40Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIn this study, radiation effect on an asthma drug Airfix and its ingredients (Montelukast sodium, Sorbitol) were analyzed by using EPR spectroscopy in the dose range of 10 Gy-30 kGy. The dependence of radiation-induced radicals on irradiation dose, temperature and time was investigated in detail. It has been determined that the radical observed predominantly in the Airfix structure originates from Sorbitol, and the characteristic features of this alkyl-type radical have been clearly defined using both experimental EPR and theoretical DFT methods. Dosimetric properties were investigated for all samples and it was suggested that Airfix drug and Sorbitol could be used as an EPR dosimeter through this radical agent which was determined to be very stable and sensitive to radiation. Moreover, it has been emphasized that other drugs containing Sorbitol excipient can also be used for dosimetric purposes in the dose range studied and even irradiation doses can be detected in case of radiation sterilization.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit (BAP) at Selcuk University in TURKEY [18401142]en_US
dc.description.sponsorshipThis work was financially supported by a project with the grant number [18401142] of Scientific Research Projects Coordination Unit (BAP) at Selcuk University in TURKEY.en_US
dc.identifier.doi10.1016/j.radphyschem.2022.110082
dc.identifier.issn0969-806X
dc.identifier.issn1879-0895
dc.identifier.scopus2-s2.0-85127005373en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.radphyschem.2022.110082
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12524
dc.identifier.volume195en_US
dc.identifier.wosWOS:000792904100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofRadiation Physics And Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpr Dosimetryen_US
dc.subjectDensity Functional Theory (Dft)en_US
dc.subject-Irradiationen_US
dc.subjectAlkyl Radicalen_US
dc.subjectMontelukast Sodiumen_US
dc.subjectSorbitolen_US
dc.titleParamagnetic characterization and dosimetric properties of Airfix drug and its ingredients (Montelukast sodium, Sorbitol): An EPR and DFT studyen_US
dc.typeArticleen_US

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