NAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgaris

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dc.contributor.authorDursun, Recep
dc.contributor.authorDursun, Hatice Gul
dc.contributor.authorZamani, Ayse Gul
dc.contributor.authorYildirim, Mahmut Selman
dc.contributor.authorCinar, Elknur
dc.date.accessioned2024-02-23T14:26:32Z
dc.date.available2024-02-23T14:26:32Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractPsoriasis is a common, chronic, and autoimmune skin disease. Factors that play a role in etiopathogenesis of psoriasis include internal factors such as genetic susceptibility and immunological factors and external factors such as stress, infection, trauma, drug, and environmental compounds. N-acetyltransferase 2 ( NAT2) is a xenobiotic enzyme that is involved in the metabolism of drugs, environmental toxins, and carcinogens. In this study, we aimed to demonstrate whether the variations in the NAT2 gene lead to a predisposition to psoriasis by affecting the enzyme's ability to metabolize drugs and environmental components or not. Three polymorphisms (rs1799929, rs1799930, and rs1799931) in NAT2 gene were genotyped and compared by real-time PCR method in 260 psoriasis vulgaris patients and 200 healthy controls. There was no difference in the genotype distributions and allele frequencies of polymorphisms between psoriasis vulgaris patients and controls. When the effects of polymorphisms on the clinical features of the disease, such as onset age and severity, are assessed, it has been found that rs1799930 and rs1799929 are, respectively, associated with early onset age and severity of the disease. In conclusion, rs1799929, rs1799930, and rs1799931 polymorphisms of the NAT-2 gene do not appear to be a risk factor for the development of psoriasis. Conversely, they may have an effect on either more severe or early onset cases of the disease.en_US
dc.description.sponsorshipNecmettin Erbakan University, Scientific Research Projects Office [121218015]en_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University, Scientific Research Projects Office (Project no. 121218015).en_US
dc.identifier.doi10.1155/2018/3258708
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid29992137en_US
dc.identifier.scopus2-s2.0-85049318653en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2018/3258708
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14240
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000434914500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleNAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgarisen_US
dc.typeArticleen_US

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