Relationship between histomorphological findings and platelet activation in psoriasis

Basit Öğe Kaydı
dc.contributor.authorEren Karanis, Meryem Ilkay
dc.contributor.authorKucukosmanoglu, Ilknur
dc.contributor.authorOltulu, Pembe
dc.contributor.authorKilinc, Fahriye
dc.contributor.authorOzer, Ilkay
dc.date.accessioned2024-02-23T14:24:30Z
dc.date.available2024-02-23T14:24:30Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground Elevated platelet count (PC), mean platelet volume (MPV), and Platelet Mass Index (PMI) are reported in patients with psoriasis, while platelet activation is associated with psoriasis severity. Available studies examining the relationship between platelet activation markers and psoriasis have mostly focused on psoriasis area severity index. To the best of our knowledge, there is no study examining the relationship between histopathological features of a single psoriatic plaque and platelet activation. The present study examined the relationship between histomorphological findings obtained by morphometric analysis and psoriasis patients' PC, MPV, and PMI values. Materials and Methods Morphometric analysis was performed on hematoxylin and eosin-stained preparations of skin biopsies to measure minimum suprapapillary epidermis thickness (SPETmin) and maximum epidermal thickness (ETmax), maximum suprapapillary keratosis thickness (SPKTmax), and maximum keratosis thickness (KTmax). The relationship between PC, MPV, PMI, and morphometric skin biopsy outcomes was evaluated. Results While an inverse correlation was found between SPETmin and PC and PMI in cases with psoriasis (p values = 0.015 and 0.005, r values = -0.238 and -0.271, respectively), no significant correlation was found between SPETmin and MPV (p value = 0.600, r value = -. 052). On the contrary, no significant correlation was found between SPKTmax, ETmax, and KTmax values and platelet parameters. Conclusion We assume that an increased risk of platelet activation-related diseases is expected in psoriasis patients displaying histopathological findings of suprapapillary thinning due to increased platelet activation; therefore, it may be beneficial to monitor these patients in terms of such risks.en_US
dc.identifier.doi10.1111/jocd.15155
dc.identifier.endpage6133en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue11en_US
dc.identifier.pmid35696281en_US
dc.identifier.scopus2-s2.0-85132557199en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6129en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.15155
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13971
dc.identifier.volume21en_US
dc.identifier.wosWOS:000815596500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMorphometric Analysisen_US
dc.subjectPlateleten_US
dc.subjectPlatelet Mass Indexen_US
dc.subjectPsoriasisen_US
dc.subjectSuprapapillary Epidermal Thicknessen_US
dc.titleRelationship between histomorphological findings and platelet activation in psoriasisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu