Nutritional characteristic of children with inflammatory bowel disease in the nationwide inflammatory bowel disease registry from the Mediterranean region

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dc.contributor.authorKuloglu, Zarife
dc.contributor.authorCetin, Funda
dc.contributor.authorUrganci, Nafiye
dc.contributor.authorOnal, Zerrin
dc.contributor.authorSari, Sinan
dc.contributor.authorYuksekkaya, Hasan
dc.contributor.authorCaltepe, Gonul
dc.date.accessioned2024-02-23T14:16:43Z
dc.date.available2024-02-23T14:16:43Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND/OBJECTIVES: We analyzed the nationwide pediatric inflammatory bowel disease (PIBD) registry (1998-2016), to evaluate the nutritional status at the time of diagnosis. SUBJECTS/METHODS: Nine types of nutritional status by the combination of weight-for-length (<2 years)/body mass index (>2 years) and length/height-for-age with three categories (<-2, -2 to 2, and >2 SD) were described. Malnutrition was defined by WHO criteria. Univariate and multivariate regression analysis was used to identify risk factors for malnutrition. RESULTS: In total, 824 IBD patients (498 Ulcerative colitis (UC); 289 Crohn's Disease (CD); 37 Indeterminate Colitis (IC); 412 male; the median age 12.5 years) were eligible. The prevalence of eutrophy, wasting/thinness, stunting, overweight, tall stature, concurrent wasting/thinness and stunting, tall stature with overweight, tall stature with wasting/thinness, and short stature with overweight were 67.4%, 14.9%, 6.6%, 3.1%, 3.2%, 3.3%, 1.1%, 0.4%, and 0.1%, respectively. The prevalence of malnutrition was 32.7%, indicating a higher prevalence in CD (p < 0.001). Incidence of overweight was less common in the CD than UC and IC (p < 0.001). Multivariate analysis revealed that age of onset (>10 years), prepubertal stage, severe disease activity, perianal involvement, and high C reactive protein level were independently associated with malnutrition in pediatric IBD. CONCLUSION: We showed the frequency of nutritional impairment in PIBD. The percentage of overweight subjects was lower than the other studies. The age of onset, disease activity, CRP level, perianal involvement, and pubertal stage were associated with a higher risk for developing malnutrition. Our results also confirmed that CD patients are particularly vulnerable to nutritional impairment.en_US
dc.description.sponsorshipSociety of Turkish Pediatric Gastroenterology, Hepatology, and Nutritionen_US
dc.description.sponsorshipThis research was funded by The Society of Turkish Pediatric Gastroenterology, Hepatology, and Nutrition.en_US
dc.identifier.doi10.1038/s41430-022-01094-6
dc.identifier.endpage1296en_US
dc.identifier.issn0954-3007
dc.identifier.issn1476-5640
dc.identifier.issue9en_US
dc.identifier.pmid35173290en_US
dc.identifier.scopus2-s2.0-85127080460en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1289en_US
dc.identifier.urihttps://doi.org/10.1038/s41430-022-01094-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12757
dc.identifier.volume76en_US
dc.identifier.wosWOS:000756527500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEuropean Journal Of Clinical Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleNutritional characteristic of children with inflammatory bowel disease in the nationwide inflammatory bowel disease registry from the Mediterranean regionen_US
dc.typeArticleen_US

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