Corneal nerve loss and increased Langerhans cells are associated with disease severity in patients with rheumatoid arthritis

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorKucuk, Adem
dc.contributor.authorErgun, Mustafa Cagri
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorMalik, Rayaz A.
dc.date.accessioned2024-02-23T14:16:44Z
dc.date.available2024-02-23T14:16:44Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground/ObjectivesRheumatoid arthritis (RA) is a multisystem autoimmune disorder characterized by articular and extra-articular manifestations. Neuropathy is a poorly studied manifestation of RA. The aim of this study was to utilize the rapid non-invasive ophthalmic imaging technique of corneal confocal microscopy to identify whether there is evidence of small nerve fibre injury and immune cell activation in patients with RA.Subjects/MethodsFifty consecutive patients with RA and 35 healthy control participants were enrolled in this single-centre, cross-sectional study conducted at a university hospital. Disease activity was assessed with the 28-Joint Disease Activity Score and erythrocyte sedimentation rate (DAS28-ESR). Central corneal sensitivity was measured with a Cochet-Bonnet contact corneal esthesiometer. A laser scanning in vivo corneal confocal microscope was used to quantify corneal nerve fibre density (CNFD), nerve branch density (CNBD), nerve fibre length (CNFL), and Langerhans cell (LC) density.ResultsCorneal sensitivity (P = 0.01), CNFD (P = 0.02), CNBD (P < 0.001), and CNFL (P < 0.001) were lower, and mature (P = 0.001) and immature LC densities (P = 0.011) were higher in patients with RA compared to control subjects. CNFD (P = 0.016) and CNFL (P = 0.028) were significantly lower in patients with moderate to high (DAS28-ESR > 3.2) compared to mild (DAS28-ESR <= 3.2) disease activity. Furthermore, the DAS28-ESR score correlated with CNFD (r = -0.425; P = 0.002), CNBD (rho = -0.362; P = 0.010), CNFL (r = -0.464; P = 0.001), total LC density (rho = 0.362; P = 0.010) and immature LC density (rho = 0.343; P = 0.015).ConclusionsThis study demonstrates reduced corneal sensitivity, corneal nerve fibre loss and increased LCs which were associated with the severity of disease activity in patients with RA.en_US
dc.description.sponsorshipScientific Research Coordination Center of Necmettin Erbakan University [201218001]en_US
dc.description.sponsorshipThis work was supported by The Scientific Research Coordination Center of Necmettin Erbakan University (Project ID: 201218001). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripten_US
dc.identifier.doi10.1038/s41433-023-02447-6
dc.identifier.endpage2955en_US
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue14en_US
dc.identifier.pmid36808180en_US
dc.identifier.scopus2-s2.0-85148345502en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2950en_US
dc.identifier.urihttps://doi.org/10.1038/s41433-023-02447-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12760
dc.identifier.volume37en_US
dc.identifier.wosWOS:000934730900001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEyeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleCorneal nerve loss and increased Langerhans cells are associated with disease severity in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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