Impact of unilateral trigeminal neuralgia on bilateral ocular surface alterations

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dc.contributor.authorAltas, Mustafa
dc.contributor.authorOltulu, Pembe
dc.contributor.authorUca, Ali Ulvi
dc.contributor.authorBelviranli, Selman
dc.contributor.authorGundogan, Ali Osman
dc.contributor.authorMirza, Enver
dc.contributor.authorOltulu, Refik
dc.date.accessioned2024-02-23T14:24:15Z
dc.date.available2024-02-23T14:24:15Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective To evaluate ocular surface alterations in both eyes of patients with unilateral trigeminal neuralgia (TN) compared with controls. Background Corneal nerves mainly originate from the trigeminal nerve, and neurosensory abnormalities are important factors in ocular surface alterations and dry eye etiopathogenesis. Methods Twenty-four patients with idiopathic unilateral TN and 24 healthy controls with similar sex and age distributions were included in this cross-sectional study conducted from February 15 to September 15, 2021. The eyes on the affected sides of the patients with TN were treated as Group 1, their contralateral eyes as Group 2, and the right eyes of the controls as Group 3. All participants were evaluated for tear film and ocular surface using the Schirmer 1 test, tear breakup time (TBUT), Ocular Surface Disease Index (OSDI) score, and conjunctival impression cytology grading. Results The mean (SD) ages of the patients with TN (17 of 24 females, 70.8%) and controls (15 of 24 females, 62.5%) were 49.7 (11.7) and 48.5 (9. 6) years, respectively. The median [25th, 75th percentile] Schirmer 1 test results in Groups 1, 2, and 3 were 5.0 [4.0, 14.0], 7.0 [3.2, 11.7], and 10.0 [6.0, 15.7] mm, respectively, with no statistically significant differences between Groups 1 and 2 (p = 0.697), Groups 1 and 3 (p = 0.133), or Groups 2 and 3 (p = 0.129). The median TBUT scores in Groups 1, 2, and 3 were 7.0 [5.0, 10.0], 8.0 [5.2, 10.0], and 12.5 [8.0, 13.0] s, respectively, showing reduced times for both Groups 1 and 2 versus Group 3 (median difference = -3.0 [95% CI: -5.0, -1.0], p = 0.001, and median difference = -3.0 [95% CI: -5.0, -2.0], p = 0.001, respectively). Conjunctival impression cytology grades were significantly higher in Groups 1 and 2 versus Group 3 (median difference = 2.0 [95% CI: 1.0, 2.0], p < 0.001, and median difference = 1.0 [95% CI: 1.0, 2.0], p < 0.001, respectively). The median OSDI score in TN patients (30.2 [25.0, 34.9]) was significantly higher than in the controls (8.3 [0.0, 18.7]), with a median difference of 20.8 (95% CI: 14.7, 27.1), p < 0.001. Conclusion Even if pain is unilateral in patients with TN, there are significant abnormalities in conjunctival cytology and tear functions in both eyes. There seem to be various pathophysiological mechanisms of TN that affect the bilateral ocular surface and lead to significant alterations.en_US
dc.identifier.doi10.1111/head.14370
dc.identifier.endpage1045en_US
dc.identifier.issn0017-8748
dc.identifier.issn1526-4610
dc.identifier.issue8en_US
dc.identifier.pmid36053073en_US
dc.identifier.scopus2-s2.0-85137357624en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1039en_US
dc.identifier.urihttps://doi.org/10.1111/head.14370
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13857
dc.identifier.volume62en_US
dc.identifier.wosWOS:000848755300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHeadacheen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBilateral Pathophysiological Mechanismen_US
dc.subjectConjunctival Impression Cytologyen_US
dc.subjectDry Eyeen_US
dc.subjectTrigeminal Neuralgiaen_US
dc.titleImpact of unilateral trigeminal neuralgia on bilateral ocular surface alterationsen_US
dc.typeArticleen_US

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