Plasma 9-cis, 11-trans ve 10-trans, 12-cis Conjugated Linoleic Acid Isomers Levels in Continuous Ambulatory Peritoneal Dialysis Patients

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dc.contributor.authorYerlikaya, Fatma Hmeyra
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorKurban, Sevil
dc.contributor.authorTonbul, Halil Zeki
dc.date.accessioned2024-02-23T14:41:24Z
dc.date.available2024-02-23T14:41:24Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: Peritoneal dialysis is a renal replacement therapy in patients with end stage renal disease. Conjugated linoleic acid (CLA) refers to a class of positional and geometric conjugated isomers of the omega-6 essential fatty acid, linoleic acid. This study aimed to investigate biologically active isomers of CLA (10-trans, 12-cis CLA and -9-cis, 11-trans CLA) and the relationship between these fatty acids and weight, body mass index (BMI), C-reactive protein (CRP) and parathyroid hormone (PTH) in continuous ambulatory peritoneal dialysis patients (CAPD) and healthy subjects. MATERIAL and METHODS: This study was performed on 51 (21M, 30F) CAPD patients at least 6 months under dialysis, aged 20-75 years and 45 (25M, 20F) healthy control subjects aged 20-60 years. Plasma 10-trans, 12-cis CLA (t10, c12 CLA) and 9-cis, 11-trans CLA (c9, t11 CLA) levels were measured by GS-MS technique. RESULTS: t10, c12 and c9, t11 isomers of CLA levels of the CAPD patients were as follows: 11.84 +/- 5.3 and 8.34 +/- 4.4 mg/L respectively. The same parameters of the controls were as follows: 12.88 +/- 4.1 and 9.20 +/- 4.5 mg/L, respectively. The differences between plasma CLA isomers levels of CAPD patients and control subjects were not significant. Isomers of CLA negatively correlated with serum PTH levels in CAPD patients. However, there was no significant correlation between plasma isomers of CLA and weight, BMI, CRP in CAPD patients. CONCLUSION: These findings suggest that a CLA-rich diet may help in reducing high levels of parathyroid hormone in the case of good control of phosphorus in CAPD patients associated with secondary hyperparathyroidism.en_US
dc.identifier.doi10.5262/tndt.2012.1003.08
dc.identifier.endpage252en_US
dc.identifier.issn1300-7718
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84866890241en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2012.1003.08
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16843
dc.identifier.volume21en_US
dc.identifier.wosWOS:000217179200008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis And Transplantation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeritoneal Dialysisen_US
dc.subjectConjugated Linoleic Aciden_US
dc.subjectParathyroid Hormoneen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectBody Mass Indexen_US
dc.titlePlasma 9-cis, 11-trans ve 10-trans, 12-cis Conjugated Linoleic Acid Isomers Levels in Continuous Ambulatory Peritoneal Dialysis Patientsen_US
dc.typeArticleen_US

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