Investigation of the effect of naringenin on oxidative stress-related alterations in testis of hydrogen peroxide-administered rats

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dc.contributor.authorSahin, Zafer
dc.contributor.authorOzkaya, Ahmet
dc.contributor.authorCuce, Gokhan
dc.contributor.authorUckun, Mirac
dc.contributor.authorYologlu, Ertan
dc.date.accessioned2024-02-23T12:11:10Z
dc.date.available2024-02-23T12:11:10Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractTestis tissue is prone to oxidation because its plasma membrane contains many polyunsaturated fatty acids. Naringenin is a plant-derived natural flavonoid. We investigated the possible ameliorative role of naringenin on the hydrogen peroxide (H2O2)-induced testicular damage in Wistar rats. Animals received 12mg/kg H2O2 by intraperitoneal injection, and 50mg/kg naringenin via orogastric gavage for 4 weeks. In the H2O2 group, the testis malondialdehyde level increased, while the amount of reduced glutathione, glutathione transferase activities, and the testis weight decreased. There were severe testicular damages in the H2O2 group otherwise their grade were less in the naringenin+H2O2 group. However, the serum testosterone concentrations decreased in both the H2O2 and the naringenin+H2O2 groups. The testicular zinc and calcium levels reduced in the H2O2-treated rats. In conclusion, the administration of H2O2 caused oxidative stress in the testes and naringenin supplementation decreased the H2O2-induced effects, except for changes in testosterone levels.en_US
dc.description.sponsorshipScientific Research Projects Unit of Adiyaman University (ADYUBAP) [FEFYL 2013/0005]en_US
dc.description.sponsorshipContract Grant Sponsor: The Scientific Research Projects Unit of Adiyaman University (ADYUBAP). This Funding agency is an local unit of the Adiyaman University. Contract Grant Number: FEFYL 2013/0005.en_US
dc.identifier.doi10.1002/jbt.21928
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue9en_US
dc.identifier.pmid28467669en_US
dc.identifier.scopus2-s2.0-85018956091en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.21928
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10574
dc.identifier.volume31en_US
dc.identifier.wosWOS:000408915800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydrogen Peroxideen_US
dc.subjectNaringeninen_US
dc.subjectOxidative Stressen_US
dc.subjectTestosteroneen_US
dc.subjectTestisen_US
dc.titleInvestigation of the effect of naringenin on oxidative stress-related alterations in testis of hydrogen peroxide-administered ratsen_US
dc.typeArticleen_US

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