An in-vitro study: The effect of surface properties on bioactivity of the oxide layer fabricated on Zr substrate by PEO

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dc.contributor.authorCengiz, Sezgin
dc.contributor.authorUzunoglu, Aytekin
dc.contributor.authorHuang, Sabrina M.
dc.contributor.authorStanciu, Lia
dc.contributor.authorTarakci, Mehmet
dc.contributor.authorGencer, Yucel
dc.date.accessioned2024-02-23T14:16:19Z
dc.date.available2024-02-23T14:16:19Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractSurface properties can affect cell attachment and growth ability on the biomaterials. In this work, the effect of the morphology and chemical composition of the surface coatings synthesized on zirconium (Zr) substrates on bioactivity was studied. The surface of pure Zr was modified via a plasma electrolytic oxidation process to obtain oxide-based coatings with different surface chemical compositions and pore sizes by changing the process parameters in the same electrolyte. The characterization of the coatings was conducted using X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle goniometry (CAG) and energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR). The results showed that the coatings comprised tZrO(2) and Ca0.134Zr0.86O1.86 phases. During the oxidation of Zr substrates, applying an anode current with different densities and frequencies altered the surface roughness Ra of the samples. The relationship between the surface morphology, chemical composition, and bioproperties was investigated by simulated body fluid (SBF) and cell culture tests. The coated samples were immersed into SBF solution and the formation of hydroxyapatite (HA) structure on the surface was detected after 7 days of immersion. A close relationship between the development of HA, the size of the porosity and chemical composition of the coating surface was observed. Additionally, the cell attachment and cell growth on the surface were found to be dependent on the chemistry and topography of coated surfaces. The cell culture test revealed that the growth of the cells was improved with increasing pore sizes on the coating surface.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2214-A, 2211-C]en_US
dc.description.sponsorshipThe authors acknowledge the helps of technicians Ahmet Nazim and Adem Sen performing the XRD and SEM measurements. In addition to, the authors express their thanks to Professor Farshid Sadeghi and Abdullah Alazemi for Zescope Optical Surface Profilometry measurements. Sezgin Cengiz acknowledges financial support of the Scientific and Technological Research Council of Turkey (TUBITAK) (Program number 2214-A and 2211-C).en_US
dc.identifier.doi10.1016/j.surfin.2020.100884
dc.identifier.issn2468-0230
dc.identifier.scopus2-s2.0-85098228380en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.surfin.2020.100884
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12625
dc.identifier.volume22en_US
dc.identifier.wosWOS:000615248300004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSurfaces And Interfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZirconiumen_US
dc.subjectPlasma Electrolytic Oxidationen_US
dc.subjectHydroxyapatiteen_US
dc.subjectSurface Morphologyen_US
dc.subjectIn-Vitroen_US
dc.subjectSaos-2 Cellen_US
dc.titleAn in-vitro study: The effect of surface properties on bioactivity of the oxide layer fabricated on Zr substrate by PEOen_US
dc.typeArticleen_US

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