Is there a link between premature ovarian failure and serum concentrations of vitamin D, zinc, and copper?

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dc.contributor.authorKebapcilar, Ayse Gul
dc.contributor.authorKulaksizoglu, Mustafa
dc.contributor.authorKebapcilar, Levent
dc.contributor.authorGonen, Mustafa Sait
dc.contributor.authorUnlu, Ali
dc.contributor.authorTopcu, Ali
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2024-02-23T14:21:09Z
dc.date.available2024-02-23T14:21:09Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjective: The risk of primary ovarian insufficiency (POI) increases in association with autoimmune conditions. Adequate intake of vitamin D (vit D) and trace elements is required for the immune system to function efficiently. The aim of this study was to evaluate vit D, zinc, and copper blood levels in women with POI who had given birth to at least one child and in women with normal menstrual cycles. Methods: This was a cross-sectional, case-control study involving 63 participants divided into two groups: the study group, which is composed of 35 women with POI, and the control group, which is composed of 28 women with normal menstrual cycles. Serum concentrations of zinc, vit D, and copper were determined for each participant. Results: Women with POI had significantly higher serum copper levels and copper-to-zinc ratio but significantly lower serum vit D and zinc levels when compared with the healthy control group. Serum follicle-stimulating hormone levels were inversely correlated with zinc and vit D levels and positively correlated with the copper-to-zinc ratio and copper levels. Vit D levels were inversely correlated with follicle-stimulating hormone levels, copper-to-zinc ratio, and copper levels and positively correlated with zinc levels. Conclusions: Most women with POI are deficient in vit D. Zinc, copper, and vit D seem to correlate with hormonal status in the participants. The present study may generate hypotheses for future studies that will investigate the possible mechanisms behind alterations in trace elements and vit D deficiency in women with POI and whether these changes could be used to screen for the risk of developing POI.en_US
dc.identifier.doi10.1097/gme.0b013e31826015ca
dc.identifier.endpage99en_US
dc.identifier.issn1072-3714
dc.identifier.issn1530-0374
dc.identifier.issue1en_US
dc.identifier.pmid22968257en_US
dc.identifier.scopus2-s2.0-84872083706en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://doi.org/10.1097/gme.0b013e31826015ca
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13454
dc.identifier.volume20en_US
dc.identifier.wosWOS:000312793400015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMenopause-The Journal Of The North American Menopause Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZincen_US
dc.subjectCopperen_US
dc.subjectVitamin Den_US
dc.subjectPrimary Ovarian Insufficiencyen_US
dc.titleIs there a link between premature ovarian failure and serum concentrations of vitamin D, zinc, and copper?en_US
dc.typeArticleen_US

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