Abnormal quantitative pupillary light responses following COVID-19

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorKorkmaz, Celalettin
dc.contributor.authorZamani, Adil
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorMalik, Rayaz A.
dc.date.accessioned2024-02-23T13:56:11Z
dc.date.available2024-02-23T13:56:11Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractPurpose To characterize alterations in pupillary light reflex responses in subjects following coronavirus disease 2019 (COVID-19), especially those with long-COVID. Methods Thirty-five subjects with previous COVID-19 and 30 healthy control participants were enrolled in this cross-sectional comparative study. An infrared dynamic pupillometry system (MonPack One; Metrovision, France) was used to quantify pupillary light responses. The National Institute for Health and Care Excellence (NICE) long-COVID questionnaire was used to identify persisting symptoms at least 4 weeks after acute COVID-19. Results The median time after the diagnosis of acute COVID-19 was 4.0 (2.0-5.0) months. There was an increase in the latency of pupil contraction (P = 0.001) and a reduction in the duration of pupil contraction (P = 0.039) in post-COVID-19 subjects compared to healthy controls. No significant differences were observed in the initial pupil diameter, amplitude and velocity of pupil contraction or latency, velocity and duration of pupil dilation. Long-COVID was present in 25/35 (71%) subjects and their duration of pupil contraction was reduced compared to subjects without long-COVID (P = 0.009). The NICE long-COVID questionnaire total score (rho = - 0.507; P = 0.002) and neurological score (rho = - 0.412; P = 0.014) correlated with the duration of pupil contraction and the total score correlated with the latency of dilation (rho = - 0.352; P = 0.038). Conclusion Dynamic pupillometry reveals significant alterations in contractile pupillary light responses, indicative of parasympathetic dysfunction after COVID-19.en_US
dc.identifier.doi10.1007/s10792-022-02275-9
dc.identifier.endpage2854en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue9en_US
dc.identifier.pmid35380318en_US
dc.identifier.scopus2-s2.0-85127572224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2847en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-022-02275-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11117
dc.identifier.volume42en_US
dc.identifier.wosWOS:000779517000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutonomic Dysfunctionen_US
dc.subjectCovid-19en_US
dc.subjectDynamic Pupillometryen_US
dc.subjectLong-Coviden_US
dc.subjectPupillary Light Reflexen_US
dc.titleAbnormal quantitative pupillary light responses following COVID-19en_US
dc.typeArticleen_US

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