Evaluation of inflammatory biomarkers in patients with keratoconus

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dc.contributor.authorOltulu, Refik
dc.contributor.authorKatipoglu, Zeynep
dc.contributor.authorGundogan, Ali Osman
dc.contributor.authorMirza, Enver
dc.contributor.authorBelviranli, Selman
dc.date.accessioned2024-02-23T14:27:05Z
dc.date.available2024-02-23T14:27:05Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: To investigate the monocyte-to-HDL-cholesterol ratio (MHR), neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocytes ratio (ELR), platelet distribution width (PDW), red blood cell distribution width (RDW), mean platelet volume (MPV), MPV to platelet count ratio (MPV/PC), and RDW to platelet ratio (RPR) that are accepted as inflammatory markers in patients with keratoconus. Methods: In this study, 43 patients with keratoconus and 43 healthy individuals as the control group were retrospectively evaluated. High density lipoprotein cholesterol (HDL-c), lymphocyte, neutrophil, eosinophil, monocyte, platelet, MPV, PDW, and RDW values were obtained with complete blood count performed on the peripheral blood samples. Results: Absolute monocyte (593 +/- 182 vs 492 +/- 177; p < 0.05) and neutrophil (4860 +/- 1553 vs 3954 +/- 1297; p < 0.01) counts were statistically significantly higher in the keratoconus groups compared to the control group. MHR (13.18 +/- 5.02 vs 9.88 +/- 4.45; p < 0.01) and NLR (2.30 +/- 0.87 vs 1.77 +/- 0.61; p < 0.01) were statistically significantly higher and LMR (4.07 +/- 1.67 vs 5.18 +/- 2.06; p < 0.01) was significantly lower in the keratoconus group. As a result of univariate logistic regression analysis, it was observed that MHR and NLR were statistically significant relationship with keratoconus (p = 0.02 and p = 0.021) (Odds ratio = 5.41 (95% CI: 1.169-6.669) and Odds ratio:5.28 (95% CI: 1.024-6.321); respectively). No statistically significant difference was found between the groups in terms of PLR, ELR, RDW, MPV, PDW, MPV/PC, and RPR. Adjusting for age and gender, multivariate regression analysis revealed that MHR was the most significant parameter to demonstrate relationship with keratoconus (p = 0.025) (Odds ratio = 4.99 (95% CI: 1.019-6.332)). Conclusion: MHR and NLR values considered as inflammatory markers were statistically significantly higher and LMR value was significantly lower in the keratoconus group. Among these values, MHR was the most reliable parameter.en_US
dc.identifier.doi10.1177/11206721211000644
dc.identifier.endpage159en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue1en_US
dc.identifier.pmid33715480en_US
dc.identifier.scopus2-s2.0-85102479768en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage154en_US
dc.identifier.urihttps://doi.org/10.1177/11206721211000644
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14445
dc.identifier.volume32en_US
dc.identifier.wosWOS:000678265300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammationen_US
dc.subjectKeratoconusen_US
dc.subjectLymphocyteen_US
dc.subjectMonocyte Ratioen_US
dc.subjectMonocyteen_US
dc.subjectHdl Ratioen_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyte Ratioen_US
dc.titleEvaluation of inflammatory biomarkers in patients with keratoconusen_US
dc.typeArticleen_US

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