Curcumin alleviates cisplatin-induced learning and memory impairments

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dc.contributor.authorOz, Mehmet
dc.contributor.authorAtalik, K. Esra Nurullahoglu
dc.contributor.authorYerlikaya, F. Humeyra
dc.contributor.authorDemir, Enver Ahmet
dc.date.accessioned2024-02-23T14:13:20Z
dc.date.available2024-02-23T14:13:20Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractThe present study has been designed to investigate the role of curcumin on cisplatin-inducedcognitive impairment and to reveal mechanisms of cisplatin's detrimental actions on cognition in rats. Animals were treated with cisplatin (5 mg/kg/week) and/or curcumin (300 mg/kg/day) for 5 weeks. Morris water maze test was used to assess spatial learning and memory. Enzymatic activities of acetylcholinesterase (AChE) and superoxide dismutase (SOD) were evaluated from hippocampus and plasma samples, and malondialdehyde (MDA), which is the end-product of lipid peroxidation, was determined by a colorimetric method. Our results showed that cisplatin (5 mg/kg/week, 5 weeks) caused learning and memory deficits, elevated MDA content, decreased SOD activity in the hippocampus and plasma, and AChE activity in the hippocampus. Curcumin improved learning and memory in rats with administration of cisplatin. In addition, curcumin significantly reduced the level of MDA and increased the activities of SOD and AChE. Taken together, our findings indicate that curcumin ameliorates cisplatin-induced spatial learning and memory impairment, possibly through restored cholinergic function and enhanced oxidative status. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Unit, Konya, Turkey [131218031]en_US
dc.description.sponsorshipThis study has been supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit, Konya, Turkey (Project no.: 131218031).en_US
dc.identifier.doi10.1016/j.nlm.2015.05.001
dc.identifier.endpage49en_US
dc.identifier.issn1074-7427
dc.identifier.issn1095-9564
dc.identifier.pmid25982942en_US
dc.identifier.scopus2-s2.0-84929590596en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1016/j.nlm.2015.05.001
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12396
dc.identifier.volume123en_US
dc.identifier.wosWOS:000359510900006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofNeurobiology Of Learning And Memoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectAcheen_US
dc.subjectCisplatinen_US
dc.subjectLearning And Memoryen_US
dc.subjectOxidative Statusen_US
dc.titleCurcumin alleviates cisplatin-induced learning and memory impairmentsen_US
dc.typeArticleen_US

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