Vitamin E and selenium treatment of monocrotaline induced hepatotoxicity in rats

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dc.contributor.authorCuce, G.
dc.contributor.authorCanbaz, H. T.
dc.contributor.authorSozen, M. E.
dc.contributor.authorYerlikaya, F. H.
dc.contributor.authorKalkan, S.
dc.date.accessioned2024-02-23T14:20:28Z
dc.date.available2024-02-23T14:20:28Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractMonocrotaline (MCT) is a hepatotoxic pyrrolizidine alkaloid that is derived from plants; exposure may occur by consumption of contaminated grains, herbal teas and medicines. MCT can cause liver damage. We investigated the antioxidant effects of selenium (Se) and vitamin E against the toxic effects of MCT. Female Wistar albino rats were divided into four groups: a control group, an MCT group, an MCT + Se group, and an MCT + vitamin E group. Liver tissues were harvested, fixed, processed to paraffin and sections were cut. Anti-von Willebrand factor (vWF) immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL), and hematoxylin and eosin staining were performed. Serum and liver tissue glutathione (GSH), catalase (CAT), and glutathione peroxidase (GPx) levels were measured. Histopathological and TUNEL data showed significantly increased liver damage in the MCT group compared to controls. Histopathological and TUNEL staining indicated significant improvements in the MCT + vitamin E and MCT + Se groups compared to the MCT group. MCT significantly reduced the serum GSH level and GPx activity, and liver GPx activity. Biochemical data indicated a significant improvement in serum GSH level in the MCT + vitamin E group compared to the MCT group. We suggest that vitamin E and Se afford limited protection against MCT hepatotoxicity.en_US
dc.description.sponsorshipScientific Research Projects Coordination Office of Necmettin Erbakan University, Konya, Turkey [151218012]en_US
dc.description.sponsorshipOur research was supported by a grant from the Scientific Research Projects Coordination Office of Necmettin Erbakan University, Konya, Turkey, Project No. 151218012.en_US
dc.identifier.doi10.1080/10520295.2016.1267798
dc.identifier.endpage67en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid28166421en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2016.1267798
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13161
dc.identifier.volume92en_US
dc.identifier.wosWOS:000395756300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalaseen_US
dc.subjectGlutathioneen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectHistopathologyen_US
dc.subjectLiveren_US
dc.subjectTunelen_US
dc.subjectGpxen_US
dc.subjectMonocrotalinen_US
dc.subjectRatsen_US
dc.subjectSeleniumen_US
dc.subjectVitamin Een_US
dc.subjectVon Willebrand Factoren_US
dc.titleVitamin E and selenium treatment of monocrotaline induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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