Oxidative stress and insulin resistance in policemen working shifts

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dc.contributor.authorDemir, Irfan
dc.contributor.authorToker, Aysun
dc.contributor.authorZengin, Selcuk
dc.contributor.authorLaloglu, Esra
dc.contributor.authorAksoy, Hulya
dc.date.accessioned2024-02-23T13:43:49Z
dc.date.available2024-02-23T13:43:49Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractShift work is a work schedule involving irregular or unusual hours, compared to those of a normal daytime work schedule. In developed countries, night shift work is very common. In several cities of our country, 12/24 shift system is implemented in police organization. While night shift work composes half of the 20 shift in a month, in ergonomic shift system, an alternative shift schedule, shift work can be performed in three shifts in a day. In this study, we aimed to investigate the effects of 12/24 shift work system on insulin resistance and oxidative stress and systemic inflammation. Two hundred and four 12/24 shift workers (age 44.3 +/- A 5.6 years) and 193 ergonomic shift workers (age 42.6 +/- A 5.5 years) were included to study. Serum oxidized LDL (ox-LDL), neutrophil gelatinase lipocalin-2 (NGAL) as oxidative stress markers, glucose, insulin, ferritin, high-sensitive C-reactive protein (hsCRP) and erythrocyte sedimentation rate values were measured. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated to evaluate insulin resistance. Serum ox-LDL, HOMA-IR, hsCRP and NGAL levels in 12/24 shift system were found to be significantly higher compared with ergonomic shift workers (p < 0.0001, p = 0.02, p = 0.03, p = 0.02, respectively). When evaluated all subjects, weak but significant correlation was found between HOMA-IR with ox-LDL (r = 0.12, p = 0.01), hsCRP (r = 0.17, p = 0.001) and ferritin (r = 0.15, r = 0.003). Also in 12/24 shift work group, there were significant correlations between HOMA-IR with hsCRP (r = 0.17, p = 0.01) and ferritin (r = 0.25, p = 0.0001). It may be concluded that 12/24 shift system might give rise to insulin resistance and oxidative stress. Additionally, workers in this system may under risk of systemic inflammatory response. Working hours must be arranged in accordance with the physiological rhythm.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112S559]en_US
dc.description.sponsorshipThis study was financially supported by a research fund from the Scientific and Technological Research Council of Turkey (TUBITAK) (112S559).en_US
dc.identifier.doi10.1007/s00420-015-1079-1
dc.identifier.endpage412en_US
dc.identifier.issn0340-0131
dc.identifier.issn1432-1246
dc.identifier.issue3en_US
dc.identifier.pmid26228659en_US
dc.identifier.scopus2-s2.0-84961050924en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.1007/s00420-015-1079-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10937
dc.identifier.volume89en_US
dc.identifier.wosWOS:000372288800004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Archives Of Occupational And Environmental Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectShift Systemen_US
dc.subjectOxidative Stressen_US
dc.subjectInsulin Resistanceen_US
dc.subjectInflammationen_US
dc.titleOxidative stress and insulin resistance in policemen working shiftsen_US
dc.typeArticleen_US

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