Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions

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dc.contributor.authorBurunsuz, Ozge
dc.contributor.authorOzdengul, Faik
dc.contributor.authorGica, Sakir
dc.contributor.authorSen, Aysu
dc.contributor.authorSahin, Zafer
dc.date.accessioned2024-02-23T14:31:38Z
dc.date.available2024-02-23T14:31:38Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Office [171318005]en_US
dc.description.sponsorshipThis project was funded by Necmettin Erbakan University Scientific Research Projects Office within the scope of the project (no. 171318005).en_US
dc.identifier.doi10.14744/DAJPNS.2022.00170
dc.identifier.endpage47en_US
dc.identifier.issn1018-8681
dc.identifier.issn1309-5749
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85128946767en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.14744/DAJPNS.2022.00170
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15267
dc.identifier.volume35en_US
dc.identifier.wosWOS:000784777300006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofDusunen Adam-Journal Of Psychiatry And Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntidepressanten_US
dc.subjectBladderen_US
dc.subjectDetrusoren_US
dc.subjectSmooth Muscle Contractionen_US
dc.subjectTrazodoneen_US
dc.titleInvestigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractionsen_US
dc.typeArticleen_US

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