Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats

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dc.contributor.authorKorucu, Ismail Hakki
dc.contributor.authorKekec, Ahmet Fevzi
dc.contributor.authorArslan, Abdullah
dc.contributor.authorOltulu, Pembe
dc.contributor.authorKorucu, Emine Nedime
dc.contributor.authorOzer, Mustafa
dc.date.accessioned2024-02-23T14:41:52Z
dc.date.available2024-02-23T14:41:52Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjectives: This study aims to investigate the effects of hyperbaric oxygen (HBO) therapy and platelet-rich plasma (PRP) on the regeneration of osteochondral defects of the rats, and the synergistic effect of this combined treatment. Materials and methods: This randomized, controlled, and interventional animal study was conducted between May 2014 and August 2014 Osteochondral regeneration was evaluated in four treatment groups (control, PRP, HBO, and HBO+PRP groups) at the 30 th day after iatrogenic injury. Thirty-two female Wistar albino rats (weighing 248-305 g) underwent arthrotomy and osteochondral surgery on left knees. The regenerations of defects were then examined histologically by the modified version of O'Driscoll score. Results: Groups that were treated with either HBO or PRP alone regenerated significantly better than the control group (p=0.01), while no significant difference was found between the HBO- and PRP-treated groups (p 0.05). The defects in group 4 (treated with both HBO and PRP) regenerated significantly better than the control group, the HBO-treated group alone, and the PRP-treated group alone (p=0.01). Conclusion: The results of this study showed a synergistic effect of HBO and PRP on knee cartilage regeneration. However, the possible underlying mechanisms should be the subject of future researches. The aggregation and activation of growth factors released from platelets whose activation is increased in the hyperbaric environment may explain this effect. This may result in a better regeneration than the effect of PRP or HBO alone.en_US
dc.identifier.doi10.5606/ehc.2020.72592
dc.identifier.endpage266en_US
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue2en_US
dc.identifier.pmid32584723en_US
dc.identifier.scopus2-s2.0-85089537713en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://doi.org/10.5606/ehc.2020.72592
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17042
dc.identifier.volume31en_US
dc.identifier.wosWOS:000545984600014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases And Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCartilage Regenerationen_US
dc.subjectHyperbaric Oxygen Therapyen_US
dc.subjectOsteochondral Defecten_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.titleRegenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of ratsen_US
dc.typeArticleen_US

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