Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine

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dc.contributor.authorGulec, Melike
dc.contributor.authorTassoker, Melek
dc.contributor.authorErturk, Mediha
dc.date.accessioned2024-02-23T14:27:19Z
dc.date.available2024-02-23T14:27:19Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground: Long-term use of L-Thyroxine (LT4), the synthetic thyroxine hormone used for thyroid hormone replacement therapy, is an important risk factor for osteoporosis. The aim of this study was to investigate the differences between mandibular cortical index (MCI) and trabecular bone fractal dimension (FD) values on panoramic radiographs of patients using LT4 and control subjects.Methods: A total of 142 female patients, 71 cases and 71 controls, were analyzed in the study. Ages were matched in case and control groups and the mean age was 36.6 +/- 8.2 (18 to 50) years. MCI consisting of C1 (Normal Mandibular Cortex), C2 (Moderately Resorbed Mandibular Cortex) and, C3 (Severely Resorbed Cortex) scores was determined for case and control groups. Fractal analysis was performed using ImageJ on selected regions of interest from the gonial and interdental regions. The box-count method was used to calculate FD values. Wilcoxon signed-rank test, Mann-Whitney U test, and Spearman correlation analysis were applied to compare the measurements. Statistical significance of differences was established at P < 0.05 level.Results: FD values did not show statistically significant differences between case and control groups (p > 0.05). The mean FD in the right gonial region was 1.38 +/- 0.07 in the case group and 1.38 +/- 0.08 in the control group (p = 0.715). The mean FD in the right interdental region was 1.37 +/- 0.06 in the cases and 1.36 +/- 0.06 in the control group (p = 0.373). The mean FD in the left gonial region was 1.39 +/- 0.07 in the cases and 1.39 +/- 0.07 in the control group (p = 0.865). The mean FD in the left interdental region is 1.37 +/- 0.06 in the cases and 1.38 +/- 0.05 in the control group (p = 0.369). The most common MCI score was C1, with 62% in the cases and 83.1% in the control group. MCI scores showed a statistically significant difference between cases and controls (p = 0.016, p < 0.05). While the C2 score was higher in the cases, the C1 score was higher in the controls.Conclusions: LT4 use was not associated with the FD of mandibular trabecular bone, but was associated with MCI values of cortical bone. Further studies on larger samples with different imaging modalities and image processing methods are needed.en_US
dc.identifier.doi10.1186/s12903-023-03670-z
dc.identifier.issn1472-6831
dc.identifier.issue1en_US
dc.identifier.pmid37986156en_US
dc.identifier.scopus2-s2.0-85177174617en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12903-023-03670-z
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14544
dc.identifier.volume23en_US
dc.identifier.wosWOS:001108062400008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Oral Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypothyroidismen_US
dc.subjectMedicationen_US
dc.subjectOsteoporosisen_US
dc.subjectMandibular Cortical Indexen_US
dc.subjectFractal Dimensionen_US
dc.subjectImage Processingen_US
dc.titleEvaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxineen_US
dc.typeArticleen_US

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