The goal of primary therapy in non-metastatic nasopharyngeal cancer should be radiological complete response

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dc.contributor.authorKorkmaz, Mustafa
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorKocak, Mehmet Zahid
dc.contributor.authorDemirkiran, Aykut
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorArtac, Mehmet
dc.date.accessioned2024-02-23T14:29:09Z
dc.date.available2024-02-23T14:29:09Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground: We aimed to investigate the effect of radiological complete response on survival outcomes in patients with non-metastatic nasopharyngeal cancer. This study is conducted as a retrospective cohort. Of the 185 patients screened, 60 were metastatic, 25 patients' data was not available, and as a result, 92 patients were included in the study. Among the complete response (CR) and incomplete response (IR) groups, overall survival (OS), distant metastasis-free survival (DMFS), and locoregional failure-free survival (LRFFS) were evaluated. Results: Of the 92 patients, 54 (58.6%) were CR and 38 (41.4%) were IR patients. Of the whole study group, the 5-year OS, DMFS, and LRFFS rates were 75%, 78%, and 95%, respectively. A significant difference was found between the 5-year OS (90% vs. 60%, p= 0.001) and DMFS (87% vs. 65%, p= 0.02) rates. However, there was no significant difference in the 5-year LRFFS rate (97% vs. 92%, p= 0.16). Complete response were determined as an independent predictor for OS (HR: 0.13, 95% CI: 0.045-0.36, p <0.001) and DMFS (HR: 0.26, 95% CI: 0.095-0.744, p= 0.012). Conclusion: As a result, the survival benefit in patients with CR after primary treatment is evident as shown in the above studies. Therefore, the aim of primary treatment should be to increase the CR rates. It is important to evaluate early tumor response to determine poor tumor regression.en_US
dc.identifier.doi10.1186/s43163-022-00267-1
dc.identifier.issn1012-5574
dc.identifier.issn2090-8539
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85133726782en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1186/s43163-022-00267-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14569
dc.identifier.volume38en_US
dc.identifier.wosWOS:000821871900002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEgyptian Journal Of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Metastatic Nasopharyngeal Canceren_US
dc.subjectPredicten_US
dc.subjectRadiological Complete Responseen_US
dc.titleThe goal of primary therapy in non-metastatic nasopharyngeal cancer should be radiological complete responseen_US
dc.typeArticleen_US

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