Comparison of Salivary Cortisol, Serum Cortisol, Plasma ACTH and Urinary Free Cortisol Levels in Thyrotoxic and Hypothyroid Patients

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dc.contributor.authorGonen, Mustafa Sait
dc.contributor.authorOzkaya, Emin
dc.contributor.authorKurban, Sevil
dc.contributor.authorIpekci, Suleyman Hilmi
dc.contributor.authorDuran, Cevdet
dc.contributor.authorKulaksizoglu, Sevsen
dc.date.accessioned2024-02-23T14:41:31Z
dc.date.available2024-02-23T14:41:31Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractObjective: Hypothalamo-pituitary-adrenal (HPA) axis is affected by thyroid hormones. The present study was designed to compare the level of salivary cortisol, serum cortisol, plasma adrenocorticotropic hormone (ACTH) and urinary free cortisol (UFC) levels in patients with subclinical and overt thyrotoxicosis and hypothyroidism. Material and Methods: We analyzed the salivary cortisol, serum cortisol, plasma ACTH and UFC levels in 123 patients with thyroid dysfunction. The patients were classified into four groups; overt thyrotoxicosis (n=32), subclinical thyrotoxicosis (n=29), overt hypothyroidism (n=28) and subclinical hypothyroidism (n=34). Results: There were no significant differences in terms of salivary cortisol, serum cortisol, plasma ACTH and UFC levels in patients with subclinical and overt thyrotcodcosis (p>0.05). Similarly, no significant differences could be detected in terms of salivary cortisol, serum cortisol, plasma ACTH and UFC levels in patients with subclinical and overt hypothyroidism (p>0.05). The comparison of patients with hypothyroidism and thyrotoxicosis also did not yield any significant difference in terms of salivary cortisol, serum conisol, plasma ACTH and UFC levels (p>0.05). Conclusion: Similar salivary cortisol, serum cortisol, plasma ACTH and UFC levels were detected in patients with hypothyroidism and thyrotoxicosis. Thus, we may suggest that thyroid hormone status does not play a role in the HPA axis. The major limitation of this study was the absence of a healthy control group. Further studies with large numbers of patients are required to clarify the association between thyroid hormone dysfunction and glucocorticoid levels.en_US
dc.identifier.doi10.5336/medsci.2010-22031
dc.identifier.endpage58en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2010-22031
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16873
dc.identifier.volume32en_US
dc.identifier.wosWOS:000302272100008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyrotoxicosisen_US
dc.subjectHypothyroidismen_US
dc.subjectCortisolen_US
dc.subjectActhen_US
dc.titleComparison of Salivary Cortisol, Serum Cortisol, Plasma ACTH and Urinary Free Cortisol Levels in Thyrotoxic and Hypothyroid Patientsen_US
dc.typeArticleen_US

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