Inconsistencies of the Disease Activity Assessment Tools for Psoriatic Arthritis: Challenges to Rheumatologists

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dc.contributor.authorGezer, Halise Hande
dc.contributor.authorDuruoz, Mehmet Tuncay
dc.contributor.authorNas, Kemal
dc.contributor.authorKilic, Erkan
dc.contributor.authorSargin, Betul
dc.contributor.authorKasman, Sevtap Acer
dc.contributor.authorAlkan, Hakan
dc.date.accessioned2024-02-23T14:12:34Z
dc.date.available2024-02-23T14:12:34Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: Currently, concerning the evaluation of psoriatic arthritis (PsA), there is no agreement on a standardized composite index for disease activity that includes all relevant domains. The present study sought to assess the rates of remission (REM)/low disease activity (LDA) and disease states [minimal disease activity (MDA), very low disease activity (VLDA)] as defined by diverse activity scales (DAPSA, DAS28-ESR) in an attempt to display discrepancies across these assessment tools for peripheral PsA. Methods: The study involved 758 patients (496 females, 262 males; mean age 47,1 years) with peripheral PsA who were registered to the Turkish League Against Rheumatism (TLAR) Network. The patients were assessed using the DAS28-ESR, DAPSA, MDA, and VLDA. The overall yield of each scale was assessed in identifying REM and LDA. The presence or absence of swollen joints was separately analysed. Results: The median disease duration was 4 years (range 0-44 years). According to DAPSA and DAS28-ESR, REM was achieved in 6.9% and 19.5% of the patients, respectively. The rates of MDA and VLDA were 16% and 2.9%, respectively. Despite the absence of swollen joints, a significant portion of patients were not considered to be in REM (296 (39.1%) patients with DAS28-ESR, 364 (48%) with DAPSA, and 394 (52%) with VLDA). Conclusion: Patients with peripheral PsA may be assigned to diverse disease activity levels when assessed with the DAS28-ESR, DAPSA, MDA and VLDA, which would inevitably have clinical implications. In patients with PsA a holistic approach seems to be necessary which includes other domains apart from joint involvement, such as skin involvement, enthesitis, spinal involvement, and patient-reported outcomes. (C) 2021 Societe franc , aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipTurkish League Against Rheumatism (TLAR)en_US
dc.description.sponsorshipThis work was supported by the Turkish League Against Rheumatism (TLAR) .en_US
dc.identifier.doi10.1016/j.jbspin.2021.105296
dc.identifier.issn1297-319X
dc.identifier.issn1778-7254
dc.identifier.issue3en_US
dc.identifier.pmid34656752en_US
dc.identifier.scopus2-s2.0-85118218068en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2021.105296
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12112
dc.identifier.volume89en_US
dc.identifier.wosWOS:000718034300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofJoint Bone Spineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRemissionen_US
dc.subjectDisease Activityen_US
dc.subjectPsoriatic Arthritisen_US
dc.subjectComposite Indexen_US
dc.titleInconsistencies of the Disease Activity Assessment Tools for Psoriatic Arthritis: Challenges to Rheumatologistsen_US
dc.typeArticleen_US

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