High digit ratio (2D:4D) is associated with attack frequency and severity in hereditary angioedema patients

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dc.contributor.authorEvcen, Recep
dc.contributor.authorColkesen, Fatih
dc.contributor.authorSaygin, Duygu Akin
dc.contributor.authorAykan, Filiz Sadi
dc.contributor.authorKilinc, Mehmet
dc.contributor.authorErgun, Ummugulsum Yilmaz
dc.contributor.authorAkkus, Fatma Arzu
dc.date.accessioned2024-02-23T14:02:43Z
dc.date.available2024-02-23T14:02:43Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground: Hereditary angioedema (HAE) caused by a deficiency or dysfunction of the plasma protease C1inhibitor is a rare autosomal-dominant disorder. We explored a possible correlation between the ratio of the second and fourth finger lengths (2D:4D) and the frequency of HEA attacks, and whether the ratio might predict laryngeal attack. Method: We evaluated 35 HEA patients aged 19 to 66 years; 3 were subsequently excluded. The 2D:4D ratio was calculated by dividing the length of the second finger by that of the fourth finger of both hands. A structured clinical questionnaire exploring HAE course and treatment over the prior year was administered.Results: Of the 32 participants, 56.25 % (n = 18) were female. Of them, those with high 2D:4D ratios suffered significantly more laryngeal attacks than others; 93.3% of patients with high 2D:4D ratios experienced >= 5 attacks annually, significantly more than those with low ratios. Among type 2 HEA patients, 75 % of those experiencing >= 5 attacks annually had high 2D:4D ratios; all patients with low 2D:4D ratios reported <5 attacks annually. These significant effects were found for right-hand 2D:4D ratios and not left-hand 2D:4D ratios.Conclusion: The data suggest that intrauterine sex hormone exposure, which affects the 2D:4D ratio, is significantly associated with HEA attack frequency and severity, and laryngeal edema.en_US
dc.identifier.doi10.1016/j.earlhumdev.2023.105724
dc.identifier.issn0378-3782
dc.identifier.issn1872-6232
dc.identifier.pmid36827749en_US
dc.identifier.scopus2-s2.0-85148756597en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.earlhumdev.2023.105724
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11824
dc.identifier.volume177en_US
dc.identifier.wosWOS:000948136900001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEarly Human Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHereditary Angioedemaen_US
dc.subject2den_US
dc.subject4d Ratioen_US
dc.subjectAttack Severityen_US
dc.subjectLaryngeal Attacksen_US
dc.subjectC1 Inhibitoren_US
dc.titleHigh digit ratio (2D:4D) is associated with attack frequency and severity in hereditary angioedema patientsen_US
dc.typeArticleen_US

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