Clinicopathological Characteristics of Gastroenteropancreatic Neuroendocrine Tumors 10 Years of Experience From a Single Center

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dc.contributor.authorSenturk, Mustafa
dc.contributor.authorAcar, Berkan
dc.contributor.authorYildirim, Mehmet Aykut
dc.contributor.authorCakir, Murat
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorVatansev, Celalettin
dc.date.accessioned2024-02-23T14:21:16Z
dc.date.available2024-02-23T14:21:16Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjectives Gastorenteropancreatic neuroendocrine (GEP-NET) tumors are the second most common tumors of the gastrointestinal tract. We aimed to investigate the clinicopathological features and factors affecting the prognosis of patients with GEP-NET. Methods Clinicopathological features of 158 patients were evaluated, including tumor location, TNM stage and grade, pathological features, presence of lymph nodes and distant metastases at the time of diagnosis, maximum tumor diameter and treatment details. Also, follow-up information was analyzed to discover possible prognostic factors. Results The most common primary site is pancreas (45.6%, n = 72). Most of the GEP-NETs were nonfunctional (93.6%, n = 148). Of the 158 patients, 94 (59.5%) were grade 1, 46 (29.1%) grade 2, and 18 (11.4%) grade 3. The 1-year, 3-year, and 5-year survival rates were 82.3% (130/158), 61.4% (70/114), and 47.2% (35/74), respectively. In multivariate analysis, histological grade (P = 0.04) and TNM stage (P < 0.001) were independent prognostic factors for survival in patients with GEP-NET. Conclusions They are increasing in frequency and are the most common tumors in the pancreas. Nonfunctional tumors made up the majority of cases. The main treatment was surgical resection. Histological grade and TNM stage are independent prognostic factors.en_US
dc.identifier.doi10.1097/MPA.0000000000001981
dc.identifier.endpage163en_US
dc.identifier.issn0885-3177
dc.identifier.issn1536-4828
dc.identifier.issue2en_US
dc.identifier.pmid35404891en_US
dc.identifier.scopus2-s2.0-85127966714en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.1097/MPA.0000000000001981
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13523
dc.identifier.volume51en_US
dc.identifier.wosWOS:000780314200019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPancreasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastroenteropancreatic Neuroendocrine Neoplasmen_US
dc.subjectSurvival Analysisen_US
dc.subjectPrognostic Factorsen_US
dc.titleClinicopathological Characteristics of Gastroenteropancreatic Neuroendocrine Tumors 10 Years of Experience From a Single Centeren_US
dc.typeArticleen_US

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