Telmisartan ameliorates oxidative stress and subarachnoid haemorrhage-induced cerebral vasospasm

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dc.contributor.authorErdi, Fatih
dc.contributor.authorKeskin, Fatih
dc.contributor.authorEsen, Hasan
dc.contributor.authorKaya, Bulent
dc.contributor.authorFeyzioglu, Bahadir
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorKaratas, Yasar
dc.date.accessioned2024-02-23T14:17:14Z
dc.date.available2024-02-23T14:17:14Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractObjectives: Growing evidence suggests that oxidative stress is one of the factors contributing to subarachnoid haemorrhage (SAH)-induced cerebral vasospasm. SAH-induced cerebral vasospam alters thioredoxin (Trx) cycle enzymes and thioredoxin-interacting protein (TXNIP) as an important endogenous antioxidant system. In this study, we have explored the effects of telmisartan on the vascular morphological changes, endothelial apoptosis, tissue oxidative stress status and the level of Trx cycle enzymes/TXNIP in a rabbit SAH model. Methods: Forty male New Zealand rabbits were randomly divided into five groups of eight rabbits each: control group, sham group, SAH group, SAH + vehicle group and SAH + telmisartan group. SAH was created by a single cisterna magna blood injection. SAH + telmisartan group received telmisartan treatment (5 mg/kg intraperitoneal, once daily) for 72 h. The brainstem tissue Trx1, Trx2, Trx reductase (TrxR), TrxR1and TXNIP levels were investigated. Total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) levels and tumour necrosis factor alpha (TNF alpha) levels were investigated. Basilar artery segments were investigated for cross-sectional area, wall thickness measurements and endothelial apoptosis. Results: Telmisartan treatment restored the lowered level of Trx1, TrxR, TAS and the expression of TrxR1 seen in SAH. Telmisartan treatment also decreased TXNIP expression, TOS, MDA and TNF alpha levels. Morphological changes of cerebral vasospasm were attenuated after treatment. Endothelial apoptosis significantly reduced. Discussion: Treatment with telmisartan ameliorates oxidative stress and SAH-induced cerebral vasospasm in rabbits. These effects of telmisartan may be associated with downregulation of TXNIP and upregulation of Trx/TrxR.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Office [131218017]en_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Office. (Project No: 131218017)en_US
dc.identifier.doi10.1080/01616412.2015.1105626
dc.identifier.endpage231en_US
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue3en_US
dc.identifier.pmid27078703en_US
dc.identifier.scopus2-s2.0-84978517807en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage224en_US
dc.identifier.urihttps://doi.org/10.1080/01616412.2015.1105626
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13008
dc.identifier.volume38en_US
dc.identifier.wosWOS:000376337600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTelmisartanen_US
dc.subjectVasospasmen_US
dc.subjectThioredoxinen_US
dc.subjectOxidative Stressen_US
dc.titleTelmisartan ameliorates oxidative stress and subarachnoid haemorrhage-induced cerebral vasospasmen_US
dc.typeArticleen_US

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