Melanocortin 3 receptor gene polymorphism is associated with polycystic ovary syndrome in Turkish population

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dc.contributor.authorHepsen, Sema
dc.contributor.authorCakal, Erman
dc.contributor.authorKarakose, Melia
dc.contributor.authorEyerci, Nilnur
dc.contributor.authorSaat, Hanife
dc.contributor.authorBeysel, Selvihan
dc.contributor.authorOztekin, Sanem
dc.date.accessioned2024-02-23T14:20:19Z
dc.date.available2024-02-23T14:20:19Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractPolycystic ovary syndrome (PCOS) is a frequent complex disorder with an ill-defined etiology. Genetic factors seem rather effective at the occurrence of the disease, however, the evidence of established various studies results are unsatisfied. We aimed to make a contribution to the genetic baseline of the disease by investigating melanocortin 3 receptor gene polymorphism in affected patients. 101 PCOS patients and 162 age-matched healthy volunteered control subjects recruited to the study. PCOS patients classified according to their BMI class and insulin resistance situation. Anthropometric measurements, physical examination results, laboratory findings, and hormone levels were recorded for each participant and analysis of two SNPs on the MC3R gene; rs3746619 and rs3827103 were performed. Although no significant difference was observed in rs3827103 polymorphism between PCOS patients and controls; rs3746619 polymorphism was determined associated with PCOS in the heritage of dominant (AA + AC) and co-dominant (AA) genotypes. Two polymorphisms did not found related to obesity and insulin resistance in PCOS subgroups analysis. MC3R gene rs 3746619 polymorphism was found associated with PCOS in the Turkish population and may make a contribution to the genetic baseline of the disease.en_US
dc.description.sponsorshipScientific Research Project of Diskapi Yildirim Beyazit Training and Research Hospitalen_US
dc.description.sponsorshipThis study was funded by the Scientific Research Project of Diskapi Yildirim Beyazit Training and Research Hospital.en_US
dc.identifier.doi10.1080/09513590.2019.1576614
dc.identifier.endpage690en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue8en_US
dc.identifier.pmid30784330en_US
dc.identifier.scopus2-s2.0-85068426510en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage685en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2019.1576614
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13116
dc.identifier.volume35en_US
dc.identifier.wosWOS:000477899300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectMelanocortin 3 Receptor Gene Polymorphismen_US
dc.subjectInsulin Resistanceen_US
dc.subjectObesityen_US
dc.titleMelanocortin 3 receptor gene polymorphism is associated with polycystic ovary syndrome in Turkish populationen_US
dc.typeArticleen_US

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