Pharmaceutical residues in digested sewage sludge: Occurrence, seasonal variation and risk assessment for soil

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dc.contributor.authorAydin, Senar
dc.contributor.authorUlvi, Arzu
dc.contributor.authorBeduk, Fatma
dc.contributor.authorAydin, Mehmet Emin
dc.date.accessioned2024-02-23T14:16:15Z
dc.date.available2024-02-23T14:16:15Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe occurrences, temporal variations and ecotoxicological risks of 38 selected pharmaceuticals from 7 therapeutic classes (i.e. antibiotics, analgesics, anti-inflammatories, beta-blockers, lipid regulators, anticancer agents, and psychiatric drugs) have been observed in the anaerobically treated sludge of the urban wastewater treatment plant (WWTP) in Konya, Turkey. Sampling was carried out to assess the seasonal variations in one year. The total daily wastewater flow rate of the WWTP was approximately 200,000 m(3)/day, and 140 tons/day of treated sludge were produced. The total concentrations of all pharmaceutical compounds ranged from 280 to 4898 mu g/kg of dry matter (dm). The dominant therapeutic class was analgesics and anti-inflammatories (49%), which was followed by antibiotics (31%). Clarithromycin and azithromycin were the most abundant compounds, with concentrations of 1496 mu g/kg dm. The total daily pharmaceutical load in the treated sludge was as high as 1.002 kg/day in the winter season, while the annual pharmaceutical mass load that was discharged into the environment was estimated to be approximately 71.6 kg. The use of treated sludge as fertilizer in agricultural lands causes continuous contamination of the terrestrial environment by pharmaceuticals. Five antibiotics (i.e., azithromycin, clarithromycin, erythromycin, sulfamethoxazole, and doxycycline), one analgesic (acetylsalicylic acid) and one beta-blocker (atenolol) in the digested sludge pose acute and short chronic high risks to environment. The highest short chronic risk in the digested sludge amended soils was determined for azithromycin (RQ: 54.9). To reduce the potential environmental impact of pharmaceuticals, digested sludge should be monitored in terms of the pharmaceutical contents before being applied to soil.en_US
dc.description.sponsorshipTurkish Academia of Sciences Awards for Outstanding Young Scientists (TuBA-GEBIP)en_US
dc.description.sponsorshipThis work was supported by Turkish Academia of Sciences Awards for Outstanding Young Scientists (TuBA-GEBIP).en_US
dc.identifier.doi10.1016/j.scitotenv.2021.152864
dc.identifier.issn0048-9697
dc.identifier.issn1879-1026
dc.identifier.pmid34998750en_US
dc.identifier.scopus2-s2.0-85123016627en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.scitotenv.2021.152864
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12585
dc.identifier.volume817en_US
dc.identifier.wosWOS:000766818100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofScience Of The Total Environmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPharmaceuticalsen_US
dc.subjectSewage Sludgeen_US
dc.subjectRisk Assessmenten_US
dc.subjectAnaerobic Digestionen_US
dc.subjectSoilen_US
dc.titlePharmaceutical residues in digested sewage sludge: Occurrence, seasonal variation and risk assessment for soilen_US
dc.typeArticleen_US

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