Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: a multicenter, randomized controlled trial

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dc.contributor.authorGundogan, Kursat
dc.contributor.authorKarakoc, Emre
dc.contributor.authorTeke, Turgut
dc.contributor.authorZerman, Avsar
dc.contributor.authorEsmaoglu, Aliye
dc.contributor.authorTemel, Sahin
dc.contributor.authorGuven, Muhammet
dc.date.accessioned2024-02-23T14:37:23Z
dc.date.available2024-02-23T14:37:23Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Critically ill patients are at risk of developing gastrointestinal (GI) bleeding due to stress causing mucosal damage. Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleeding in low risk critically ill patients. Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit (ICU) patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group (received oral/EN plus pantoprazole) and control group (received only oral/EN). Results: A total of 300 patients (intervention group: 152, control group: 148) participated in the study. Overall, 226 (75%) patients were fed by orally and 74(25%) patients fed by enteral tube feeding. Median duration of nutritional support 4 (range: 2-33) days. Overt upper GI bleeding was noted only in one patient (0.65%) who was in the intervention group. The overall length of ICU stay of 4 (2-105) days, while ICU stay was significantly longer in the intervention group than in the control group (P = 0.006). Conclusions: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritional support, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event (GI bleeding) rate and limited power.en_US
dc.description.sponsorshipNESTLE companyen_US
dc.description.sponsorshipWe thank NESTLE company for supporting the study with providing research nurse staff in study sites. NESTLE was not involved in the study hypothesis/design, execution, analysis, or interpretation.en_US
dc.identifier.doi10.3906/sag-1911-42
dc.identifier.endpage783en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid32151119en_US
dc.identifier.scopus2-s2.0-85087035100en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage776en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1911-42
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16086
dc.identifier.volume50en_US
dc.identifier.wosWOS:000613005100017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCritical Illnessen_US
dc.subjectEnteral Nutritionen_US
dc.subjectPantoprazoleen_US
dc.subjectGastrointestinal Bleedingen_US
dc.subjectStress Ulceren_US
dc.titleEffects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: a multicenter, randomized controlled trialen_US
dc.typeArticleen_US

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