Use of Eculizumab in Thrombotic Microangiopathy Associated with Hematopoietic Stem Cell Transplantation

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dc.contributor.authorDemircioglu, Sinan
dc.contributor.authorDogan, Ali
dc.contributor.authorDemir, Cengiz
dc.date.accessioned2024-02-23T14:34:23Z
dc.date.available2024-02-23T14:34:23Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractThrombotic microangiopathy (TMA) associated with hematopoietic stem cell transplantation, remains a difficult complication due to its high mortality rate, lack of standardised diagnostic criteria, and limited treatment options. Although the etiology of the disease is not clear, medications, radiotherapy, graft-versus-host disease (GVHD), angioinvasive fungal, viral infections and complement activation have been implicated. Agents such as therapeutic plasma exchange (TPE), steroids, rituximab, defibrotide, eculizumab are used in its treatment. The use of treatments such as TPE, steroids, defibrotide, and rituximab did not yield satisfactory results in transplant-associated TMA (TA-TMA). Recent studies have reported successful results with eculizumab in the treatment of TA-TMA. As there is no standard dose for eculizumab in the treatment of TA-TMA, doses used in atypical hemolytic uremic syndrome (aHUS) were administered. In this paper, we present a case that was unresponsive to TPE and steroids, but which was successfully treated with eculizumab.en_US
dc.identifier.doi10.29271/jcpsp.2021.11.1359
dc.identifier.endpage1361en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue11en_US
dc.identifier.pmid34689499en_US
dc.identifier.scopus2-s2.0-85117919817en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1359en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2021.11.1359
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15588
dc.identifier.volume31en_US
dc.identifier.wosWOS:000711314600021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectStem Cell Transplantationen_US
dc.subjectThrombotic Microangiopathyen_US
dc.subjectApheresisen_US
dc.subjectEculizumaben_US
dc.titleUse of Eculizumab in Thrombotic Microangiopathy Associated with Hematopoietic Stem Cell Transplantationen_US
dc.typeArticleen_US

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