Moderate hypothermia and responses to calcium channel blockers - Role of the nitric oxide

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dc.contributor.authorCanbolat, S.
dc.contributor.authorAtalik, K. E. Nurullahoglu
dc.date.accessioned2024-02-23T14:30:03Z
dc.date.available2024-02-23T14:30:03Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractModerate hypothermia (25-31 degrees C) may have a significant influence on vascular tone. At present, very little is known about the role of endothelial nitric oxide on the hypothermia-induced responses. In this study, we investigated the effect of hypothermia (to 28 degrees C) on the vasodilatation induced by verapamil, a phenylalkylamine calcium channel blocker (10(-9)-3 x 10(-4) M) and dihydropyridines, amlodipine (10(-9)-3 x 10(-4) M), and benidipine (10(-9)-10(-3) M) on 5-hydroxytryptamine (5-HT or serotonin) precontracted calf cardiac veins. Furthermore, the role of nitric oxide in the hypothermia-induced responses was analyzed. Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 15 ml of Krebs-Henseleit solution, maintained at 37 degrees C, and continuously gassed with 95% O-2-5% CO2. After a resting period, verapamil, amlodipine, and benidipine were applied cumulatively on serotonin (10(-6) M) precontracted calf cardiac vein rings and induced concentration-dependent relaxations. In another part of the study, the medium temperature was decreased to 28 degrees C after the preparations were contracted with 5-HT, then cumulative concentrations of verapamil, amlodipine, or benidipine were added. During hypothermia, the pIC(50) value, but not the maximal response, to all blockers were significantly higher than at 37 degrees C. Hypothermia in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) decreased the pIC(50) and E-max values to verapamil, amlodipine, and benidipine. Only one blocker was tested in each preparation. These results suggest that nitric oxide may play a role in the hypothermia-induced changes in vasodilation caused by verapamil, amlodipine, and benidipine in calf cardiac vein, but further research is needed to explain the complete mechanism.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Necmettin Erbakan University, Konya, Turkey [161318003]en_US
dc.description.sponsorshipThis study has been supported by the Scientific Research Projects Coordination Unit of Necmettin Erbakan University, Konya, Turkey (project no.: 161318003).en_US
dc.identifier.doi10.1556/2060.105.2018.1.2
dc.identifier.endpage60en_US
dc.identifier.issn2498-602X
dc.identifier.issue1en_US
dc.identifier.pmid29602295en_US
dc.identifier.scopus2-s2.0-85046370901en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1556/2060.105.2018.1.2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14985
dc.identifier.volume105en_US
dc.identifier.wosWOS:000428949500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofPhysiology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmlodipineen_US
dc.subjectBenidipineen_US
dc.subjectCardiac Veinen_US
dc.subjectHypothermiaen_US
dc.subjectNitric Oxideen_US
dc.subjectVerapamilen_US
dc.titleModerate hypothermia and responses to calcium channel blockers - Role of the nitric oxideen_US
dc.typeArticleen_US

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