Exploring the association between depression, suicidality and serum neurotrophin levels in adolescents

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorSadic, Cagla Celikkol
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorAkca, Omer Faruk
dc.date.accessioned2024-02-23T14:20:33Z
dc.date.available2024-02-23T14:20:33Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective: The aim of this study was to identify potential differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and neurotrophin-3 (NTF3) levels in adolescents with major depressive disorder (MDD) compared to healthy controls. The possible relationship between serum neurotrophin levels and suicidality in adolescents with MDD was also addressed. Methods: A total of 70 treatment-free adolescents with MDD and 40 healthy controls aged 11 to 19 years were enrolled. The severity of suicidality was determined using the Columbia-Suicide Severity Rating Scale, and the severity of depression and anxiety symptoms were evaluated by self-report inventories. Serum levels of neurotrophins were measured using an enzyme-linked immunosorbent assay. Results: The mean serum BDNF levels were significantly higher in adolescents with MDD than in control subjects; no significant difference was found between the groups for serum GDNF, NGF and NTF3 levels. No correlations were found between the levels of serum neurotrophins and the severity of depression or suicidality. Conclusions: The study results suggest that elevated serum BDNF levels may be related to MDD in adolescents. However, our findings did not support a role for neurotrophins in suicidality.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [182518001-334]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project no: 182518001-334).en_US
dc.identifier.doi10.1080/13651501.2020.1723643
dc.identifier.endpage150en_US
dc.identifier.issn1365-1501
dc.identifier.issn1471-1788
dc.identifier.issue2en_US
dc.identifier.pmid32027188en_US
dc.identifier.scopus2-s2.0-85079468184en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1080/13651501.2020.1723643
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13210
dc.identifier.volume24en_US
dc.identifier.wosWOS:000513095000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Psychiatry In Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressionen_US
dc.subjectSuicideen_US
dc.subjectNeurotrophinen_US
dc.subjectAdolescenten_US
dc.titleExploring the association between depression, suicidality and serum neurotrophin levels in adolescentsen_US
dc.typeArticleen_US

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