Serum uric acid may predict development of progressive acute kidney injury after open heart surgery

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dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorSolak, Yalcin
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorToker, Aysun
dc.contributor.authorBaysal, Ahmet Nihat
dc.contributor.authorCicekler, Humeyra
dc.contributor.authorBiyik, Zeynep
dc.date.accessioned2024-02-23T14:34:36Z
dc.date.available2024-02-23T14:34:36Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjectives: Acute kidney injury (AKI) is a common complication of cardiac surgery developing in 25-35% cases. Recently, neutrophil gelatinase-associated lipocalin (NGAL) was shown to predict AKI development earlier than serum creatinine. Some studies demonstrated the predictive role of post-operative serum uric acid (SUA) as an early marker of AKI. We aimed to study the role of serum and urine NGAL as well as SUA to predict progression of AKI. Design and methods: This is a prospective observational study of patients undergoing cardiac surgery. Blood and urine samples for measurement of uric acid, serum and urine NGAL levels were collected prior to cardiac surgery (0 h), and in the time course at 2nd and 24th hours after surgery. Patients who developed AKI were divided into two subgroups as progressing and non-progressing AKI. Results: Sixty patients (42 males, 18 females) were included. After cardiac surgery, 40 patients developed AKI, 20 of whom non-progressing AKI, and 20 progressing AKI. All of the markers significantly increased in AKI patients. A receiver operator characteristics (ROC) curve analysis showed higher predictive ability of SUA for progressing AKI compared with serum and urine NGAL. When compared markers obtained at the second hour after surgery, UA had significantly large AUC than NGAL to predict AKI developed at 24 and 48 h, particularly in patients, who require renal replacement therapy (RRT). Conclusion: Uric acid seems to predict the progression of AKI and RRT requirement in patients underwent cardiac surgery better than NGAL.en_US
dc.description.sponsorshipEuropean Renal Association - European Dialysis and Transplant Association [ERA-EDTA LTF 65-2010]en_US
dc.description.sponsorshipDr A.G. was supported in performing the present study by Long-Term Fellowship training award from the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA LTF 65-2010). This study was awarded first best oral presentation at 29th annual congress of Turkish Society of Nephrology (2012).en_US
dc.identifier.doi10.3109/0886022X.2014.976130
dc.identifier.endpage102en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid25347234en_US
dc.identifier.scopus2-s2.0-84919459402en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2014.976130
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15662
dc.identifier.volume37en_US
dc.identifier.wosWOS:000346633700016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectCardiac Surgeryen_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.subjectUric Aciden_US
dc.titleSerum uric acid may predict development of progressive acute kidney injury after open heart surgeryen_US
dc.typeArticleen_US

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