EFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICE

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dc.contributor.authorKurban, Sevil
dc.contributor.authorAnnagur, Ali
dc.contributor.authorAltunhan, Huseyin
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorOrs, Rahmi
dc.contributor.authorErdem, Said Sami
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.date.accessioned2024-02-23T14:45:54Z
dc.date.available2024-02-23T14:45:54Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an anti oxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns. Material and Method: The study was performed on 40 full-tenn newborns between 3 to 15 days of age exposed to phototherapy. SerumPON1 activity and TAC levels of the babies were determined before and after phototherapy by spectrophotometric assays. Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001). Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules.en_US
dc.identifier.endpage51en_US
dc.identifier.issn1305-2381
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17684
dc.identifier.volume10en_US
dc.identifier.wosWOS:000346628200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNobel Ilacen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhototherapyen_US
dc.subjectNeonatal Hyperbilirubinemiaen_US
dc.subjectParaoxonaseen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.titleEFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICEen_US
dc.typeArticleen_US

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