The Effect of Zinc Deficiency and Supplementation on Elements in the Kidney Tissue of Ovariectomized Rats: Histopathologic Changes

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dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorSunar, Fusun
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorToy, Hatice
dc.date.accessioned2024-02-23T14:16:38Z
dc.date.available2024-02-23T14:16:38Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe objective of the present study is to determine the effects of zinc deficiency in and zinc supplementation to ovariectomized rats on some elements in kidney tissue. The study included 40 Sprague-Dawley type adult female rats. The experimental animals were randomized into four groups with equal numbers as follows: Group 1: Control (10). Group 2: Ovariectomized control (10). Group 3: Ovariectomized + zinc supplemented (10). Group 4: Ovariectomized + zinc deficient (10). After the animals were decapitated at the end of the experiment, element levels were determined by Atomic Emission (ICP-AES) as mg/g/wet tissue for calcium, phosphate, zinc, aluminum, copper, iron, lithium, and manganese and mu g/g/wet tissue for magnesium in the kidney tissue. Additionally, the tissue samples were subjected to a histopathologic assessment. An examination of the study results showed that ovariectomy significantly reduced calcium, phosphorus, and zinc levels, while zinc supplementation to the rats following ovariectomy restored the reduced element levels to normal (0.10 +/- 0.03, 0.85 +/- 0.16, 0.11 +/- 0.03 vs 0.19 +/- 0.06, 1.86 +/- 0.18, 0.52 +/- 0.05). Group 4, which was both ovariectomized and fed on a zinc-deficient diet, had significantly lower aluminum, copper, and lithium values. Calcification, inflammation, and sclerotic changes in group 4, the group which was fed on a zinc-deficient diet, were greater in comparison to other groups (p < 0.05). Results of the study suggest that ovariectomy + zinc deficiency leads to calcification, inflammation, and sclerotic changes in renal tissue and significantly reduces element levels, whereas zinc supplementation after ovariectomy restores the lowered element levels to normal.en_US
dc.identifier.doi10.1024/0300-9831/a000396
dc.identifier.endpage138en_US
dc.identifier.issn0300-9831
dc.identifier.issn1664-2821
dc.identifier.issue3.Nisen_US
dc.identifier.pmid30816794en_US
dc.identifier.scopus2-s2.0-85066279202en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000396
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12743
dc.identifier.volume87en_US
dc.identifier.wosWOS:000468731600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerlag Hans Huberen_US
dc.relation.ispartofInternational Journal For Vitamin And Nutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectOvariectomyen_US
dc.subjectZinc Supplementationen_US
dc.subjectZinc Deficiencyen_US
dc.subjectElementsen_US
dc.titleThe Effect of Zinc Deficiency and Supplementation on Elements in the Kidney Tissue of Ovariectomized Rats: Histopathologic Changesen_US
dc.typeArticleen_US

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