The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: A prospective study

Basit Öğe Kaydı
dc.contributor.authorCicek, Ismet Esra
dc.contributor.authorCicek, Erdinc
dc.contributor.authorKayhan, Fatih
dc.contributor.authorUguz, Faruk
dc.contributor.authorErayman, Ibrahim
dc.contributor.authorKurban, Sevil
dc.contributor.authorYerlikaya, F. Humeyra
dc.date.accessioned2024-02-23T14:13:02Z
dc.date.available2024-02-23T14:13:02Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: The aim of the study was to research the relationship between interferon (IFN) induced depression and sociodemographic characteristics, neurotrophic factors and oxidative stress. Methods: Sixty four cases, 34 with Chronic Hepatitis B (CHB) and 30 with Chronic Hepatitis C (CNC), were included in the study. The patients were assessed with Structured Clinical Interview for DSM-IV (SCID-I), Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS) at baseline on the 2nd and 6th weeks of treatment. S100 calcium binding protein B (S100B), brain-derived neurotrophic factor (BDNF), total antioxidant status (TAS) and total oxidative stress (TOS) levels were measured at the same visits. Results: In total, 20 patients were diagnosed with major depression (MD) on the sixth week. A significant relationship was found between depression developed after IFN therapy and baseline HARS scores and the type of IFN-alpha. When the pretreatment levels of HDRS, HARS, S100B, BDNF, TAS, and TOS were compared to those after treatment on the 2nd week, there was a significant increase in HDRS and HARS levels and a significant decrease in the levels of S1 00B and BDNF. No significant change was determined for TAS and TOS levels. Conclusions: Our study suggests that the pathogenesis of IFN induced depression may involve neurotrophic factors. (c) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipResearch Fund of Selcuk University [09102003]en_US
dc.description.sponsorshipThis study was supported by a grant from the Research Fund of Selcuk University (Project number: 09102003). The Ethics Committee of Selcuk University School of Medicine approved the study.en_US
dc.identifier.doi10.1016/j.jpsychores.2014.01.003
dc.identifier.endpage232en_US
dc.identifier.issn0022-3999
dc.identifier.issn1879-1360
dc.identifier.issue3en_US
dc.identifier.pmid24529042en_US
dc.identifier.scopus2-s2.0-84893719133en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychores.2014.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12269
dc.identifier.volume76en_US
dc.identifier.wosWOS:000331925500007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychosomatic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterferonen_US
dc.subjectDepressionen_US
dc.subjectNeurotrophic Factorsen_US
dc.subjectOxidative Stressen_US
dc.titleThe roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: A prospective studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu