QT interval alterations in epilepsy: A thorough investigation between epilepsy subtypes

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dc.contributor.authorGurses, Asli Akyol
dc.contributor.authorGenc, Emine
dc.contributor.authorGurses, Kadri Murat
dc.contributor.authorAltiparmak, Taylan
dc.contributor.authorYildirim, Irem
dc.contributor.authorGenc, Bulent Oguz
dc.date.accessioned2024-02-23T14:12:54Z
dc.date.available2024-02-23T14:12:54Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjectives: Cardiac disturbances and rhythm abnormalities which potentially lead sudden unexpected death in epilepsy, have been extensively studied in focal epilepsies. However, studies including generalized epilepsies are scarce and it is not clear whether electrocardiogram parameters reflecting vulnerability to ventricular arrhythmias differ between these groups.Methods: Medical records of patients who were followed in epilepsy department of a tertiary center between October 2015 and September 2016 were retrospectively reviewed. 66 generalized and 64 focal epilepsy patients with eligible electrophysiological data were analyzed. QTc interval, QTcd and other electrocardiographic indices were compared between patients with focal vs generalized epilepsy. Another analysis was performed in order to disclose any difference between patients with epilepsy (n:130) and psychogenic non-epileptic seizures. A two-tailed p value < 0.05 was considered significant.Results: There was no difference in terms of QTc and QTcd between patients with focal and generalized epilepsy [median: 406 ms vs 404 ms, p = 0.119; and median: 46 ms vs 44 ms, p = 0.497, respectively]. However patients with epilepsy were found to have longer QTc and QTcd when compared to ones with psychogenic non-epileptic seizures (p = 0.035 and p < 0.001, respectively).Conclusion: Current findings demonstrate that patients with epilepsy have longer QTc and QTcd than patients with pure psychogenic non-epileptic seizures. Since there was no difference between patients with focal and generalized epilepsy; QTc interval, QTcd and potential susceptibility to cardiac arrhythmias as a result, could be a consequence of epilepsy itself regardless of origin.en_US
dc.identifier.doi10.1016/j.jocn.2022.08.014
dc.identifier.endpage117en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid36027652en_US
dc.identifier.scopus2-s2.0-85136484772en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2022.08.014
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12237
dc.identifier.volume104en_US
dc.identifier.wosWOS:000850692100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectFocal Epilepsyen_US
dc.subjectGeneralized Epilepsyen_US
dc.subjectEcgen_US
dc.subjectCardiac Arrhythmiaen_US
dc.titleQT interval alterations in epilepsy: A thorough investigation between epilepsy subtypesen_US
dc.typeArticleen_US

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