An electrochemical chiral sensor based on electrochemically modified electrode for the enantioselective discrimination of D-/L-tryptophan

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dc.contributor.authorErbilen, Nesibe
dc.contributor.authorZor, Erhan
dc.contributor.authorSaf, Ahmet Ozgur
dc.contributor.authorAkgemci, Emine Guler
dc.contributor.authorBingol, Haluk
dc.date.accessioned2024-02-23T13:55:54Z
dc.date.available2024-02-23T13:55:54Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractChirality is a universal characteristic of natural systems and discrimination of enantiomers of a chiral molecule plays a major role particularly in chemical biology and in pharmacology. In this study, a novel electrochemical chiral sensor was developed for direct discrimination of D- and L-tryptophan (Trp) in an aqueous medium. The chiral sensor was produced by hierarchical modification of reduced graphene oxide, gold nanoparticles, poly-L-cysteine, and poly-L-phenylalanine methyl ester on the glassy carbon electrode. Each of the layers was produced by electrochemical techniques, such as electrochemical reduction and polymerization. After structural and morphological characterizations, the electrochemical behaviors of the enantiomeric pairs of Trp at the modified electrode were investigated by cyclic voltammetry and square wave voltammetry. A distinctive separation between the oxidation peak potentials of D- and L-Trp was observed at 0.73 and 0.83 V, respectively. In order to investigate the amperometric response towards D- and L-Trp, chronoamperometry technique was also used in the concentration range of 0.1-0.8 mM. Furthermore, the electrochemical performance of the modified electrodes was investigated in a mixed solution of D- and L-Trp. The results showed that the prepared electrode could be used as an electrochemical chiral sensor for Trp enantiomers.en_US
dc.description.sponsorshipNecmettin Erbakan University, Research Foundation [BAP-141210005]en_US
dc.description.sponsorshipThis work was financially supported by the Necmettin Erbakan University, Research Foundation (BAP-141210005).en_US
dc.identifier.doi10.1007/s10008-019-04370-x
dc.identifier.endpage2705en_US
dc.identifier.issn1432-8488
dc.identifier.issn1433-0768
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85071526949en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2695en_US
dc.identifier.urihttps://doi.org/10.1007/s10008-019-04370-x
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11013
dc.identifier.volume23en_US
dc.identifier.wosWOS:000484549900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Solid State Electrochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnantioselective Sensoren_US
dc.subjectErgoen_US
dc.subjectAunpsen_US
dc.subjectElectro-Polymerizationen_US
dc.subjectD- And L-Tryptophanen_US
dc.titleAn electrochemical chiral sensor based on electrochemically modified electrode for the enantioselective discrimination of D-/L-tryptophanen_US
dc.typeArticleen_US

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