Impact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multi-center study

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dc.contributor.authorGok, Kevser
dc.contributor.authorNas, Kemal
dc.contributor.authorTekeoglu, Ibrahim
dc.contributor.authorSunar, Ismihan
dc.contributor.authorKeskin, Yasar
dc.contributor.authorKilic, Erkan
dc.contributor.authorSargin, Betul
dc.date.accessioned2024-02-23T13:43:43Z
dc.date.available2024-02-23T13:43:43Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThis article aims to evaluate the possible effect of obesity on quality of life, psychological status, and other clinical variables in Psoriatic arthritis (PsA). PsA patients have been recruited by the Turkish League Against Rheumatism-Network from various centers in Turkey in this cross-sectional study. Patients with a body mass index (BMI) >= of 30 kg/m(2) were considered obese. Differences among patients with regard to obesity status were assessed with health-related quality of life measures (PsA Quality of Life Questionnaire [PsAQoL]), psychological status (Hospital Anxiety and Depression Scale [HADS]), and disease activity parameters (the Disease Activity index for PSoriatic Arthritis [DAPSA], Disease Activity Score 28-C-reactive protein [DAS28-CRP], Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Psoriasis Area and Severity Index [PASI]), physical functions (Ankylosing Spondylitis Functional Index [BASFI], Health Assessment Questionnaire [HAQ], and Health Assessment Questionnaire for the spondyloarthropathies [HAQ-S]). Pain was assessed using visual analog scale of pain (VAS-P), and fatigue was evaluated using visual analog scale of fatigue (VAS-F) and Functional Assessment of Chronic Illness Therapy (FACIT). A total of 1033 patients with PsA, 650 (62.9%) non-obese and 383 (37.1%) obese were included in the study. The PsAQoL, HADS-Anxiety, HADS-Depression, DAPSA, DAS28-CRP, BASDAI, BASFI, HAQ and HAQ-S scores of the obese group were higher than the non-obese group (p < 0.05). VAS-P and PASI scores were similar between group of patients with and without obesity. Obese patients had higher median scores of VAS-F and FACIT than non-obese patients (p < 0.05). Linear regression analysis showed that BMI affects the quality of life, depression, and disease activity. Consequently, obesity has significant associations with higher disease activity, lower QoL, risk of anxiety, depression, and fatigue. Therefore, obesity should also be taken into account in the management of PsA patients.en_US
dc.identifier.doi10.1007/s00296-021-04971-8
dc.identifier.endpage668en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue4en_US
dc.identifier.pmid34453579en_US
dc.identifier.scopus2-s2.0-85113804909en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage659en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-021-04971-8
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10888
dc.identifier.volume42en_US
dc.identifier.wosWOS:000690697700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriatic Arthritisen_US
dc.subjectObesityen_US
dc.subjectQuality Of Lifeen_US
dc.subjectAnxietyen_US
dc.subjectDepressionen_US
dc.subjectDisease Activityen_US
dc.titleImpact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multi-center studyen_US
dc.typeArticleen_US

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