Beneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fraction

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dc.contributor.authorBuyuklu, Mutlu
dc.contributor.authorKandemir, Fatih Mehmet
dc.contributor.authorSet, Turan
dc.contributor.authorBakirci, Eftal Murat
dc.contributor.authorDegirmenci, Husnu
dc.contributor.authorHamur, Hikmet
dc.contributor.authorTopal, Ergun
dc.date.accessioned2024-02-23T13:59:43Z
dc.date.available2024-02-23T13:59:43Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe aim of study was to determine the effects of ozone therapy on the oxidative stress, cardiac functions and clinical findings in patients with heart failure reduced ejection fraction (HFrEF). A total of 40 patients with New York Heart Association 2 and 3 HF with left ventricular ejection fraction (LVEF) < 35%, and 40 subjects without HF as control group were included in the study. Patients with HFrEF were given additional ozone therapy of major and minor administrations along with conventional HF treatment for 5 weeks. Before and after ozone therapy, left ventricular end-systolic and end-diastolic volumes (LVESV, LVEDV) and the 6 minute walk distance (6MWD) and blood levels of the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GSHPx), malondialdehyde (MDA), nitric oxide (NO) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured. Ozone therapy significantly reduced the serum levels of NO and MDA (p < 0.001, respectively) and significantly increased the levels of SOD, CAT, GSH and GSHPx (p < 0.001, respectively). LVEDV and LVESV were found to be significantly reduced; however, LVEF was not found to be significantly increased (p = 0.567). As the biochemical improvement marker of HF, NT-proBNP was significantly reduced (p < 0.001). The clinical HF improvement marker of 6 minute walk distance was also modestly increased (p < 0.001). Ozone therapy might be beneficial in terms of activating antioxidant system and merit further therapeutic potential to conventional HF treatment in patients with HFrEF.en_US
dc.description.sponsorshipScientific Research Fund of Erzincan Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Erzincan University.en_US
dc.identifier.doi10.1007/s12012-017-9400-8
dc.identifier.endpage433en_US
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.issue4en_US
dc.identifier.pmid28097518en_US
dc.identifier.scopus2-s2.0-85009822924en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage426en_US
dc.identifier.urihttps://doi.org/10.1007/s12012-017-9400-8
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11298
dc.identifier.volume17en_US
dc.identifier.wosWOS:000411104600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofCardiovascular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeart Failureen_US
dc.subjectOzone Therapyen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidant Systemen_US
dc.titleBeneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fractionen_US
dc.typeArticleen_US

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