The value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitus

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dc.contributor.authorTaner, Alpaslan
dc.contributor.authorUnlu, Ali
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorTekinalp, Mehmet
dc.contributor.authorAyhan, Selim S.
dc.contributor.authorAribas, Alpay
dc.contributor.authorErdem, Said Sami
dc.date.accessioned2024-02-23T14:02:11Z
dc.date.available2024-02-23T14:02:11Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractBackground: An increased prevalence of masked hypertension (MHT) has been demonstrated among patients with diabetes mellitus (DM). MHT appears to cause cardiovascular (CV) complications similar to clinically overt hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased CV risk in both the general population and among patients with DM. The aim of this study was to evaluate the relationship between MHT and ADMA in diabetic patients. Methods: This study included DM patients (n = 131) with normal office blood pressure (<140/90 mmHg). None of the participants were using antihypertensive medications. All participants utilized an ambulatory blood pressure monitor (ABPM) for 24 h. Serum ADMA and arginine levels were measured using the fluorescence detector high performance liquid chromatography method. Results: The prevalence of MHT was 24.4% among the study subjects. ADMA levels were increased in the MHT group when compared with normotensive diabetics (6.2 +/- 2.2 vs 4.2 +/- 1.7 mu mol/L p = 0.001, respectively). Furthermore, arginine/ADMA ratio was lower in the MHT group than among the normotensive group (29.9 +/- 12.1 vs 46.0 +/- 19.0 p = 0.001). In the multivariate logistic regression model, ADMA, BMI and HDL levels were found to be independent predictors of MHT Odds ratio: 1.63 (1.28-2.06), 1.19 (1.05-1.35), and 0.95 (0.90-0.99), respectively. The cut-off value of the ADMA was 4.34 mu mol/L with a sensitivity, specificity, positive predictive value, and negative predictive value of 84.4%, 59.6%, of 40.3%, and 92.2%, respectively (AUC - 0.78). Conclusions: Serum ADMA may play a role in both the pathophysiology and screening of MHT in DM subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Investigation and Project Foundation of Selcuk University [09102016]; Selcuk Universityen_US
dc.description.sponsorshipThis study was financially supported by Scientific Investigation and Project Foundation of Selcuk University (Project number: 09102016).; This project was supported by Selcuk University Scientific Research Projects Fund. (BAP).en_US
dc.identifier.doi10.1016/j.atherosclerosis.2013.02.024
dc.identifier.endpage437en_US
dc.identifier.issn0021-9150
dc.identifier.issn1879-1484
dc.identifier.issue2en_US
dc.identifier.pmid23540293en_US
dc.identifier.scopus2-s2.0-84878113918en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage432en_US
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2013.02.024
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11626
dc.identifier.volume228en_US
dc.identifier.wosWOS:000319037200023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofAtherosclerosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdmaen_US
dc.subjectMasked Hypertensionen_US
dc.subjectBlood Pressureen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectType 2en_US
dc.titleThe value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitusen_US
dc.typeArticleen_US

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