The role of tryptophan metabolic pathway in children with attention deficit hyperactivity disorder with and without comorbid oppositional defiant disorder and conduct disorder

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dc.contributor.authorSaglam, Ebru
dc.contributor.authorBilgic, Ayhan
dc.contributor.authorAbusoglu, Sedat
dc.contributor.authorUnlu, Ali
dc.contributor.authorSivrikaya, Abdullah
dc.date.accessioned2024-02-23T14:13:39Z
dc.date.available2024-02-23T14:13:39Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractAccumulating data presented that tryptophan metabolic pathway (TMP) may play a role in attention-deficit/ hyperactivity disorder (ADHD). However, no study have investigated potential role of TMP in disruptive behavior disorders coexisting with ADHD. This study compared serum levels of tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine and 3-hydroxyantranilic acid in medication-free children with ADHD combined presentation (ADHD-C), with ADHD-C and oppositional defiant disorder (ODD), and with ADHD-C and conduct disorder (CD) versus healthy controls. The study also compared several ratios that are previously suggested to reflect the activities of the KP enzymes (kynurenine/tryptophan, kynurenic acid/kynurenine, 3-hydroxykynurenine/kynurenine) or neuroprotective activity (kynurenic acid/3-hydroxykynurenine) among groups. A total of 122 patients were enrolled: 46 children with ADHD-C alone, 43 children with ADHD-C+ODD, 33 children with ADHD-C+CD and 50 healthy controls. Targeted biochemical molecules were assessed by liquid chromatography-mass spectrometry/mass spectrometry. Compared to control group, serum kynurenine levels were significantly higher in the ADHD-C group, serum 3-hydroxykynurenine levels were significantly lower in the ADHD-C and ADHD-C+ODD groups, the serum kynurenic acid/kynurenine ratio was significantly higher in the ADHD-C, ADHD-C+ODD and ADHD-C+CD groups, and the serum 3-hydroxykynurenine/kynurenine ratio was significantly lower in the ADHD-C group. These findings suggest that TMP may play a role in the pathophysiology of ADHD-C.en_US
dc.description.sponsorshipScientifc Research Project Coordination Unit of Necmettin Erbakan University [181,518,011]en_US
dc.description.sponsorshipThe study was financially supported by Scientifc Research Project Coordination Unit of Necmettin Erbakan University (Project no: 181,518,011).en_US
dc.identifier.doi10.1016/j.psychres.2021.113770
dc.identifier.issn0165-1781
dc.identifier.issn1872-7123
dc.identifier.pmid33545424en_US
dc.identifier.scopus2-s2.0-85100440626en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2021.113770
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12519
dc.identifier.volume298en_US
dc.identifier.wosWOS:000634552600019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttention-Deficiten_US
dc.subjectHyperactivity Disorderen_US
dc.subjectOppositional Defiant Disorderen_US
dc.subjectConduct Disorderen_US
dc.subjectTryptophan Metabolic Pathwayen_US
dc.subjectKynurenine Pathwayen_US
dc.titleThe role of tryptophan metabolic pathway in children with attention deficit hyperactivity disorder with and without comorbid oppositional defiant disorder and conduct disorderen_US
dc.typeArticleen_US

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