Evaluation of the Effectiveness of the 6 Warning Signs of the European Society for Immunodeficiencies for Primary Immunodeficiencies in Older Adults

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dc.contributor.authorYildiz, Eray
dc.contributor.authorColkesen, Fatih
dc.contributor.authorEvcen, Recep
dc.contributor.authorAykan, Filiz Sadi
dc.contributor.authorKilinc, Mehmet
dc.contributor.authorArslan, Sevket
dc.date.accessioned2024-02-23T14:26:42Z
dc.date.available2024-02-23T14:26:42Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Diagnostic delay in cases of primary immunodeficiency (PID) is a significant problem for clinicians, and most do not have sufficient awareness of this uncommon disorder. The European Society for Immunodeficiencies (ESID) has developed 6 warning signs to increase awareness of adult PIDs. The aim of this study was to determine the prevalence of PID in older adults regardless of the reason for presentation and to evaluate the effectiveness of the 6 warning signs of ESID in the diagnosis of PIDs. Methods: The study included 1,331 patients aged >= 65 years who presented at our clinic for any reason and were questioned about the ESID 6 warning signs for PIDs. After the exclusion of reasons for secondary immunodeficiency (SID), all the patients underwent immunological evaluation for the diagnosis of potential underlying PIDs. Results: After excluding 6 patients diagnosed with SID, PID was diagnosed in 16 (1.2%) of 1,325 older adults using ESID warning signs. The most common reasons for presentation were infection (69%) in the PID group and urticaria and/or angioedema (41.5%) in the non-PID group. The most common PID subgroup was common variable immunodeficiency (50%). In 12 of the patients diagnosed with PID, there was at least 1 positive ESID warning sign. In 4 patients, PID was determined despite negative ESID warning signs. The patients diagnosed with PID showed a significant, minimal level of agreement with questions 1 and 4 of the ESID warning signs (p < 0.001, kappa = 0.204, p = 0.005, kappa = 0.208, respectively). Conclusion: The ESID warning signs do not encompass all the symptoms and findings of PIDs. There is a need for more infection-centered questions to determine PIDs in older adults. Therefore, the ESID warning signs should be further developed.en_US
dc.identifier.doi10.1159/000535604
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.pmid38219730en_US
dc.identifier.scopus2-s2.0-85182903732en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1159/000535604
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14297
dc.identifier.wosWOS:001144737600001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives Of Allergy And Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary Immunodeficiencyen_US
dc.subjectCommon Variable Immunodeficiencyen_US
dc.subjectOlder Adultsen_US
dc.subjectImmunosenescenceen_US
dc.subjectEuropean Society For Immunodeficienciesen_US
dc.subjectWarning Signsen_US
dc.titleEvaluation of the Effectiveness of the 6 Warning Signs of the European Society for Immunodeficiencies for Primary Immunodeficiencies in Older Adultsen_US
dc.typeArticleen_US

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