Pharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literature

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dc.contributor.authorUguz, Faruk
dc.date.accessioned2024-02-23T14:02:03Z
dc.date.available2024-02-23T14:02:03Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective: This review examined the efficacy of mood stabilizers and antipsychotics in patients with bipolar disorder during pregnancy and the postpartum period. Methods: PubMed was searched for reports between 01 January 1996 and 31 December 2019 by using combinations of key words bipolar disorder, pregnancy, postpartum period, puerperium, prophylaxis, mood stabilizers, antipsychotics, lithium, lamotrigine, valproate, carbamazepine, oxcarbazepine, olanzapine, risperidone, quetiapine, aripiprazole, haloperidol, and chlorpromazine. Results: The present reports included a total of 256 patients using lithium (n = 143), lamotrigine (n = 73), valproate (n = 17), olanzapine (n = 17), quetiapine (n = 4) and haloperidol (n = 1) during pregnancy or the postpartum period. Recurrence rates in pregnant patients using lithium (n = 79) and lamotrigine (n = 17) were 22.7 % and 41.2 %, respectively. According to very limited data, none of the patients using valproate (n = 2), quetiapine (n = 3) or olanzapine (n = 6) experienced a new episode during pregnancy. A recurrence was reported in 12 (70.6 %) of 17 patients using valproate during the postpartum period. The same recurrence rates in patients using lithium (n = 123), lamotrigine (n = 63), olanzapine (n = 17) and quetiapine (n = 3) were 20.3 %, 7.9 %, 11.7 %, and 33.3 %, respectively. Conclusions: This review suggests that lithium, lamotrigine and olanzapine seem to be effective in preventing new mood episodes in patients with bipolar disorder during the perinatal period.en_US
dc.identifier.doi10.1016/j.ajp.2020.102145
dc.identifier.issn1876-2018
dc.identifier.issn1876-2026
dc.identifier.pmid32516746en_US
dc.identifier.scopus2-s2.0-85086004640en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajp.2020.102145
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11556
dc.identifier.volume52en_US
dc.identifier.wosWOS:000573651300047en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofAsian Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectPregnancyen_US
dc.subjectPostpartum Perioden_US
dc.titlePharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literatureen_US
dc.typeReview Articleen_US

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