Postinfectious bronchiolitis obliterans masked by misdiagnosis as asthma

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dc.contributor.authorOnay, Zeynep R.
dc.contributor.authorGursoy, Tugba Ramasli
dc.contributor.authorAslan, Ayse T.
dc.contributor.authorEyuboglu, Tugba Sismanlar
dc.contributor.authorKibar, Busra S.
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorHangul, Melih
dc.date.accessioned2024-02-23T13:03:30Z
dc.date.available2024-02-23T13:03:30Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjectives Asthma and postinfectious bronchiolitis obliterans (PIBO) have similar clinical findings, and PIBO may be misdiagnosed with asthma. This study aimed to determine the clinical features of PIBO in children and the causes of delay in its diagnosis. Methods We retrospectively evaluated all patients diagnosed with PIBO in four pediatric pulmonology centers between 2007 and 2018. In total, 64 PIBO patients were retrospectively reviewed. We compared the clinical and laboratory differences between PIBO patients who had initially been misdiagnosed with asthma and correctly diagnosed with PIBO. Results Of the 64 patients, 22 (34.4%) had initially been misdiagnosed with asthma. Adenovirus was the most common infectious agent in children. The age upon diagnosis was older, and the symptom duration was significantly longer in patients misdiagnosed with asthma (P < .05). There were no statistical differences in terms of sex, history of prematurity, duration of hospitalization, treatment, history of oxygen or mechanical ventilation support, pulmonary function test (PFT) results and asthma-predisposing findings between the two groups (P > .05). Conclusions Patients with PIBO who had initially been misdiagnosed with asthma were correctly diagnosed at older ages and had longer symptom duration. Asthma may mask PIBO diagnosis by the similarity of symptoms and the clinical response to inhaled beta 2-agonist or steroid treatment. PFTs may not help clinicians because of the age of children. The delay in the diagnosis of PIBO is probably attributable to the fact that some clinicians fail to include PIBO in the differential diagnosis when there is no clinical response to asthma medication.en_US
dc.identifier.doi10.1002/ppul.24690
dc.identifier.endpage1011en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue4en_US
dc.identifier.pmid32049442en_US
dc.identifier.scopus2-s2.0-85079405138en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1007en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.24690
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10645
dc.identifier.volume55en_US
dc.identifier.wosWOS:000512825200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsthmaen_US
dc.subjectChildrenen_US
dc.subjectPostinfectious Bronchiolitis Obliteransen_US
dc.titlePostinfectious bronchiolitis obliterans masked by misdiagnosis as asthmaen_US
dc.typeArticleen_US

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