Uric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Disease

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dc.contributor.authorSolak, Yalcin
dc.contributor.authorAkilli, Hakan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAribas, Alpay
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorTurk, Suleyman
dc.contributor.authorPerez-Pozo, Santos E.
dc.date.accessioned2024-02-23T14:24:31Z
dc.date.available2024-02-23T14:24:31Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractIntroduction Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD). Aim This study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin. Methods This is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED. Main Outcome Measures The short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score <= 21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST. Results One hundred forty-nine of 312 (47.7%) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio = 1.36, P = 0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate. Conclusion Subjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels.en_US
dc.description.sponsorshipERA-EDTA fellowship program; NIH/NCRR Colorado CTSI [UL1 RR025780]en_US
dc.description.sponsorshipDr. A.G. received grant support from the ERA-EDTA fellowship program. No sources of funding were used to conduct this study or prepare this manuscript. Dr. Kim McFann is supported in part by NIH/NCRR Colorado CTSI Grant Number UL1 RR025780.en_US
dc.identifier.doi10.1111/jsm.12332
dc.identifier.endpage172en_US
dc.identifier.issn1743-6095
dc.identifier.issn1743-6109
dc.identifier.issue1en_US
dc.identifier.pmid24433559en_US
dc.identifier.scopus2-s2.0-84892672928en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.1111/jsm.12332
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13990
dc.identifier.volume11en_US
dc.identifier.wosWOS:000334331800020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Sexual Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUric Aciden_US
dc.subjectErectile Dysfunctionen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectEndothelial Dysfunctionen_US
dc.titleUric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Diseaseen_US
dc.typeArticleen_US

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