EXPRESSION OF MSH-6 IMMUNOHISTOCHEMISTRY MARKER IN COLORECTAL CANCER

Basit Öğe Kaydı
dc.contributor.authorRamezani, M.
dc.contributor.authorAleagha, Z. Aalami
dc.contributor.authorAlmasi, A.
dc.contributor.authorKhazaei, S.
dc.contributor.authorOltulu, P.
dc.contributor.authorSadeghi, M.
dc.date.accessioned2024-02-23T14:34:42Z
dc.date.available2024-02-23T14:34:42Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: Defects in mismatch repair genes or microsatellite instability (MSI) are seen in colorectal cancers (CRCs) both in sporadic and more predominantly in hereditary cases. Loss of MutS homolog (MSH)-6 as a mismatch repair gene may be seen in the CRC. We aimed at evaluating the expression of MSH-6 as a marker of MSI in a common tumor with hereditary and familial features for preventive, diagnostic, and therapeutic purposes. Patients and Methods: Paraffin blocks of 103 patients who underwent colonoscopy or excisional biopsy with a pathologic diagnosis of CRC were selected and immunohistochemistry (IHC) with MSH-6 marker was done. Results: Of all patients, 53 (51.45%) were males and the age range was 29-87 years. Of these, 96 (93.2%) were positive for the MSH-6 marker and 7 (6.8%) were negative. Of the 103 patients, 96 had adenocarcinoma. No significant relationship was observed between MSH-6 marker and gender, age group, cancer location in the colon, and cancerous type (p-values: 0.261, 0.343, 0.75, and 0.401, respectively). Out of 7 cases with MSH-6 loss, female gender, early-onset (<= 50 years), mucinous or poorly differentiated, proximal location, and absence of lymph node involvement were seen in 5, 4, 3, 3, and 5 cases, respectively. Conclusions: According to the results and literature, MSH-6 IHC on CRC specimens is recommended especially in young age females, with right-sided tumors, poor differentiation, and mucinous component. First-degree relatives of the patients with MSH-6 loss may be trained for strictly following the guidelines of colorectal cancer screening.en_US
dc.description.sponsorshipResearch Council of Kermanshah University of Medical Sciences, Kermanshah, Iran [97600]en_US
dc.description.sponsorshipThis research with a grant number of 97600 was funded by the Research Council of Kermanshah University of Medical Sciences, Kermanshah, Iran.en_US
dc.identifier.doi10.32113/wcrj_20215_1989
dc.identifier.issn2372-3416
dc.identifier.scopus2-s2.0-85110291057en_US
dc.identifier.urihttps://doi.org/10.32113/wcrj_20215_1989
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15721
dc.identifier.volume8en_US
dc.identifier.wosWOS:000677589300001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofWorld Cancer Research Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMicrosatellite Instabilityen_US
dc.subjectMsh-6en_US
dc.subjectColorectal Canceren_US
dc.titleEXPRESSION OF MSH-6 IMMUNOHISTOCHEMISTRY MARKER IN COLORECTAL CANCERen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu