Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue

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dc.contributor.authorBozkaya, F.
dc.contributor.authorAtli, M. O.
dc.contributor.authorGuzeloglu, A.
dc.contributor.authorKayis, S. A.
dc.contributor.authorYildirim, M. E.
dc.contributor.authorKurar, E.
dc.contributor.authorYilmaz, R.
dc.date.accessioned2024-02-23T14:24:01Z
dc.date.available2024-02-23T14:24:01Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe aim was to investigate the effects of long-term heat stress and dietary restriction on the expression of certain genes involving in steroidogenic pathway and small heat-shock proteins (sHSPs) in rat testis. Sprague Dawley rats (n = 24) were equally divided into four groups. Group I and II were kept at an ambient temperature of 22 degrees C, while Groups III and IV were reared at 38 degrees C for 9 weeks. Feed was freely available for Group I and Group III, while Group II and Group IV were fed 60% of the diet consumed by their ad libitum counterparts. At the end of 9 weeks, testicles were collected under euthanasia. Total RNA was isolated from testis tissue samples. Expression profiles of the genes encoding androgen-binding protein, follicle-stimulating hormone receptor, androgen receptor, luteinising hormone receptor, steroidogenic acute regulatory protein (StAR), cyclooxygenase-2 and sHSP genes were assessed at mRNA levels using qPCR. Long-term heat stress decreased the expression of StAR and HspB10 genes while dietary restriction upregulated StAR gene expression. The results suggested that long-term heat stress negatively affected the expression of StAR and HspB10 genes and the dietary restriction was able to reverse negative effect of heat stress on the expression of StAR gene in rat testis.en_US
dc.description.sponsorshipHarran University Scientific Research Council [12035]en_US
dc.description.sponsorshipThis study received financial support of Harran University Scientific Research Council (Grant No: 12035).en_US
dc.identifier.doi10.1111/and.12668
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid27659778en_US
dc.identifier.scopus2-s2.0-84988908526en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.12668
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13780
dc.identifier.volume49en_US
dc.identifier.wosWOS:000408624600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDietary Restrictionen_US
dc.subjectHeat Stressen_US
dc.subjectShspen_US
dc.subjectSteroidogenesisen_US
dc.titleEffects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissueen_US
dc.typeArticleen_US

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