Evaluation of peripheral lymphadenopathy with excisional biopsy: six-year experience

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dc.contributor.authorOzkan, Esra Akyuz
dc.contributor.authorGoret, Ceren Canbey
dc.contributor.authorOzdemir, Zeynep Tuba
dc.contributor.authorYanik, Serdar
dc.contributor.authorGoret, Nuri Emrah
dc.contributor.authorDogan, Meryem
dc.contributor.authorCihan, Fatma Goksin
dc.date.accessioned2024-02-23T14:48:43Z
dc.date.available2024-02-23T14:48:43Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: Lymphadenopathy (LAP) may be the first symptom of many diseases. We aimed to investigate peripheral LAP results taken by excisional biopsy. Methods: Histopathological examination of 185 lymph node biopsy specimens were evaluated between January 2009 and April 2015 in Istanbul Private Ekin Pathology Laboratory, retrospectively. Results: The average age of patients ranged from 1 to 86 was 41.01 +/- 20.62 years. 87 of were female, 98 of male. 62 (33.5%) of excisional biopsy materials were benign lesions and 123 (66.5%) of malignant. Benign lesions were consisted of reactive hyperplasia, cat-scratch disease, toxoplasmosis, necrotizing/nonnecrotizing granulomatous. Of these patients, 40 had nodes with reactive hyperplasia (15 female/25 male, mean age: 27.35 y), 14 had necrotizing granulomatous disease (9 female/5 male, mean age: 39.86 y), 2 non-necrotizing granulomatous disease (1 female/1 male mean age: 43 y), 4 had cat-scratch disease (1 female/3 male mean age: 54.25 y), 1 toxoplasmosis (26 y, female), 1 Kikuchi disease (25 y, female). In the evaluation of malign lesions; 38 were Hodgkin lymphoma (HL) (20.5%, 17 female/21 male, mean age: 34.89 y) 77 had non-Hodgkin lymphoma (NHL) (41.6%, 37 female/40 male, mean age: 52.26 y), 8 metastasis (4.3%, 5 female/3 male, mean age: 53.5 y). Reactive LAP observed most common in cervical region, NHL in axillary-abdomen-inguinal-mediastinum and HL in the supraclavicular region. Conclusion: Excisional biopsy can be applied safely with minimal morbidity and mortality and a gold standard diagnostic method for LAP. Although LAP is mostly related with benign lesions, malignancy should be kept in mind in differential diagnosis.en_US
dc.identifier.endpage15239en_US
dc.identifier.issn1936-2625
dc.identifier.issue11en_US
dc.identifier.pmid26823872en_US
dc.identifier.scopus2-s2.0-85013460234en_US
dc.identifier.startpage15234en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17802
dc.identifier.volume8en_US
dc.identifier.wosWOS:000368140100180en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenignen_US
dc.subjectExcisional Biopsyen_US
dc.subjectLymphadenopathyen_US
dc.subjectMalignanten_US
dc.titleEvaluation of peripheral lymphadenopathy with excisional biopsy: six-year experienceen_US
dc.typeArticleen_US

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